Study of a Dengue Vaccine (V180) in Healthy Adults (V180-001)

PHASE1CompletedINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

July 23, 2012

Primary Completion Date

January 23, 2014

Study Completion Date

December 11, 2014

Conditions
Dengue
Interventions
BIOLOGICAL

Low-dose V180 with low-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of low-dose V180 containing low-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Low-dose V180 with medium-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of low-dose V180 containing medium-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Medium-dose V180 (non-adjuvanted)

Three 0.5-mL intramuscular doses of medium-dose V180 with no adjuvant at Months 0, 1, and 2

BIOLOGICAL

Medium-dose V180 with low-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of medium-dose V180 containing low-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Medium-dose V180 with medium-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of medium-dose V180 containing medium-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Medium-dose V180 with Alhydrogel™ adjuvant

Three 0.5-mL intramuscular doses of medium-dose V180 containing Alhydrogel™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

High-dose V180 (non-adjuvanted)

Three 0.5-mL intramuscular doses of high-dose V180 with no adjuvant at Months 0, 1, and 2

BIOLOGICAL

High-dose V180 with low-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of high-dose V180 containing low-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

High-dose V180 with medium-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of high-dose V180 containing medium-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Low-dose V180 with high-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of low-dose V180 containing high-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Medium-dose V180 with high-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of medium-dose V180 containing high-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

High-dose V180 with high-dose ISCOMATRIX™ adjuvant

Three 0.5-mL intramuscular doses of high-dose V180 containing high-dose ISCOMATRIX™ adjuvant at Months 0, 1, and 2

BIOLOGICAL

Placebo

Three 0.5-mL intramuscular doses of phosphate-buffered saline at Months 0, 1, and 2

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT01477580 - Study of a Dengue Vaccine (V180) in Healthy Adults (V180-001) | Biotech Hunter | Biotech Hunter