72
Participants
Start Date
August 31, 2012
Primary Completion Date
March 31, 2016
Study Completion Date
March 31, 2016
High Dose Citrulline
Initial intravenous bolus of 20mg/kg (to a maximum of 1500mg) L-citrulline over 10 minutes. Immediately after the initial bolus, a continuous intravenous infusion of L-citrulline at 9mg/kg (max 700mg) per hour will be administered through a dedicated intravenous line or port of a multilumen catheter for 4 days
Placebo
D5W IV fluids at isovolumetric rate (about 15ml/hr)
Low Dose Citrulline
Initial intravenous bolus of 10mg/kg (to a maximum of 1500mg) L-citrulline over 10 minutes. Immediately after the initial bolus, a continuous intravenous infusion of L-citrulline at 4.5mg/kg (max 350mg) per hour will be administered through a dedicated intravenous line or port of a multilumen catheter for 4 days.
Vanderbilt University, Nashville
National Institutes of Health (NIH)
NIH
Vanderbilt University
OTHER