Sulfamethoxazole Drug Interaction Study With MMX® Mesalazine/Mesalamine

PHASE1CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

November 7, 2011

Primary Completion Date

December 20, 2011

Study Completion Date

December 20, 2011

Conditions
Healthy
Interventions
DRUG

sulfamethoxazole + MMX placebo

800 mg sulfamethoxazole/160 mg trimethoprim twice daily (BID) + MMX Mesalazine/mesalamine placebo once daily (QD) orally for 3 days, then a single dose of 800 mg sulfamethoxazole/160 mg trimethoprim + single does of MMX Mesalazine/mesalamine placebo orally on Day 4.

DRUG

Sulfamethoxazole + MMX Mesalazine/mesalamine

800 mg sulfamethoxazole/160 mg trimethoprim BID + 4.8 g MMX Mesalazine/mesalamine QD for 3 days, then a single dose of 800 mg sulfamethoxazole/160 mg trimethoprim + a single dose of 4.8 g MMX Mesalazine/mesalamine on Day 4

Trial Locations (1)

66219

PRA Inrernational, Lenexa

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Shire

INDUSTRY