Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

December 31, 2015

Study Completion Date

March 31, 2017

Conditions
StrokeInfarction, Middle Cerebral Artery
Interventions
GENETIC

Autologous BMSCs transplantation

"The first transplantation: 2.5 million cells per kg autologous BMSCs suspended in 100 ml saline plus 5% autologous serum are infused intravenously approximately 4 weeks after bone marrow aspiration.~The second transplantation: the same amount of cells are again transplanted approximately 1 weeks after initial boosting."

GENETIC

Autologous EPCs transplantation

"The first transplantation: 2.5 million cells per kg autologous EPCs suspended in 100 ml saline plus 5% autologous serum are infused intravenously approximately 4 weeks after bone marrow aspiration.~The second transplantation: the same amount of cells are again transplanted approximately 1 weeks after initial boosting."

GENETIC

IV infusion of placebo

IV infusion of saline plus 5% autologous serum.

Trial Locations (1)

510282

Zhujiang Hospital, Southern Medical University, Guangzhou

Sponsors
All Listed Sponsors
collaborator

The Second People's Hospital of Nanhai District of Foshan

UNKNOWN

collaborator

The First People's Hospital of Haizhu District Guangzhou

OTHER

collaborator

Cellonis Biotechnology Co. Ltd.

INDUSTRY

lead

Southern Medical University, China

OTHER