5,177
Participants
Start Date
October 7, 2013
Primary Completion Date
September 29, 2017
Study Completion Date
October 17, 2017
IV isotonic saline
The investigators will administer 3 ml/kg of isotonic saline over 1 hour at an infusion rate of not less than 1 mL/kg per hour and not more than 3 mL/kg per hour prior to the angiographic procedure, 1-1.5ml/kg per hour during angiography, and 6 ml/kg of isotonic saline over 4 hours following the procedure at an infusion rate of not less than 1 mL/kg per hour and not more than 1.5 mL/kg per hour. Providers will retain discretion to administer larger volumes of isotonic saline (up to a maximum of 12 mL/kg) over durations of up to 12 hours pre and 12 hours post-procedure.
IV isotonic bicarbonate
The investigators will administer 3 ml/kg of isotonic bicarbonate over 1 hour at an infusion rate of not less than 1 mL/kg per hour and not more than 3 mL/kg per hour prior to the angiographic procedure, 1-1.5ml/kg per hour during angiography, and 6 ml/kg of isotonic bicarbonate over 4 hours following the procedure at an infusion rate of not less than 1 mL/kg per hour and not more than 1.5 mL/kg per hour. Providers will retain discretion to administer larger volumes of isotonic bicarbonate (up to a maximum of 12 mL/kg) over durations of up to 12 hours pre and 12 hours post-procedure.
N-acetylcysteine
NAC will be administered at a dose of 1200mg orally 1 hour prior to angiography, 1 hour following the procedure, and then twice daily for the next 4 days.
Placebo
A placebo study drug capsule will be administered orally 1 hour prior to angiography, 1 hour following the procedure, and then twice daily for the next 4 days.
Wellington Hospital, Newtown
Auckland City Hospital, Auckland
Royal North Shore Hospital, St Leonards
Concord Hospital, Concord
Liverpool Hospital, Liverpool
St. George Hospital, Kogarah
Gosford Hospital, Gosford
Canberra Hospital, Canberra
Nepean Hospital, Kingswood
Northern Health, Epping
Austin Health, Heidelberg
Taranaki Base Hospital, Westown
Flinders Medical Centre, Bedford Park
Royal Perth Hospital, Perth
Sir Charles Gairdner Hospital, Nedlands
Fremantle Hospital, Fremantle
Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY, New York
Penang Hospital, George Town
VA Western New York Healthcare System, Buffalo, NY, Buffalo
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
Hunter Holmes McGuire VA Medical Center, Richmond, VA, Richmond
Salem VA Medical Center, Salem, VA, Salem
Durham VA Medical Center, Durham, NC, Durham
Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur
Charlie Norwood VA Medical Center, Augusta, GA, Augusta
North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville
Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines
Memphis VA Medical Center, Memphis, TN, Memphis
Hospital Serdang, Sepang
Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
Dayton VA Medical Center, Dayton, OH, Dayton
VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor
University of Malaya Medical Center, Kuala Lumpur
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
Jesse Brown VA Medical Center, Chicago, IL, Chicago
St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Kansas City VA Medical Center, Kansas City, MO, Kansas City
Oklahoma City VA Medical Center, Oklahoma City, OK, Oklahoma City
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
Michael E. DeBakey VA Medical Center, Houston, TX, Houston
South Texas Health Care System, San Antonio, TX, San Antonio
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
Southern Arizona VA Health Care System, Tucson, Tucson
VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
San Francisco VA Medical Center, San Francisco, CA, San Francisco
Portland VA Medical Center, Portland, OR, Portland
VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle
Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR, Little Rock
VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis
VA Boston Healthcare System West Roxbury Campus, West Roxbury, MA, West Roxbury
New Mexico VA Health Care System, Albuquerque, NM, Albuquerque
Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston
The George Institute
OTHER
VA Office of Research and Development
FED