A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Patients With HER2-Positive Advanced Gastric Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

December 6, 2011

Primary Completion Date

March 1, 2015

Study Completion Date

October 31, 2017

Conditions
Gastric Cancer
Interventions
DRUG

Capecitabine

1000 mg/m2 twice daily, from the evening of Day 1 to the morning of Day 15 of each cycle

DRUG

Cisplatin

80 mg/m2 on Day 1 of each cycle

DRUG

Pertuzumab

loading dose of 840 mg, then 420 mg once every three weeks

DRUG

Pertuzumab

840 mg once every three weeks

DRUG

Trastuzumab

loading dose of 8 mg/kg for Cycle 1 and a dose of 6 mg/kg for subsequent cycles

Trial Locations (24)

1200

Cliniques Universitaires St-Luc, Brussels

3000

UZ Leuven Gasthuisberg, Leuven

10117

Charité-Universitätsm. Berlin; Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunolo., Berlin

20133

Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2, Milan

28046

Hospital Universitario La Paz; Servicio de Oncologia, Madrid

29200

Hopital Morvan, Brest

34298

CRLCC Val dAurelle Paul Lam, Montpellier

38114

Klinikum Braunschweig; Medizinische Klinik III; Klinik für Hämatologie und Onkologie, Braunschweig

46010

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia

51092

Hopital Robert Debre; DERMATOLOGIE, Reims

56100

A.O. Universitaria Pisana; Oncologia, Pisa

60488

Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie, Frankfurt

68167

Klinikum Mannheim III. Medizinische Klinik, Mannheim

88100

Campus Universitario S.Venuta; Centro Oncologico T.Campanella, Catanzaro

656 53

Masaryk Memorial Cancer Institute; Oncological Clinic, Brno

500 05

Fakultni Nemocnice Hradec Kralove; Dept of Radiotherapy & Oncology, Hradec Králové

779 00

Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc

150 06

Fakultní Nemocnice V Motole; Radioterapeuticko-Onkologicke Oddeleni, Prague

180 81

University Hospital Na Bulovce; Institut of Radiation Oncology, Prague

6229 HX

Academish Ziekenhuis Maastricht (Azm); Inwendige Geneeskunde, Maastricht

03080

Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology, Seoul

03722

Yonsei Medical Center; Dept. of Medicine , Division of Hemato-Oncology, Seoul

05505

Asan Medical Center; Medical Oncology, Seoul

08003

Hospital del Mar; Servicio de Oncologia, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01461057 - A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Patients With HER2-Positive Advanced Gastric Cancer | Biotech Hunter | Biotech Hunter