Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

December 20, 2018

Study Completion Date

December 31, 2024

Conditions
Vasovagal Syncope
Interventions
DRUG

midodrine hydrochloride

Target dose is midodrine hydrochloride or placebo pills 10 mg three times a day for 12 months. The starting dose is 5mg q4h x3, and if tolerated a forced titration up to 10mg/dose. If there is an intolerance, then the dose can be reduced to 2.5mg/dose.

DRUG

matching placebo

The target dose in this study is 10mg q4h x3 for 12 months. The starting dose is 5mg q4h x3, and if tolerated a forced titration up to 10mg/dose. If there is an intolerance, then the dose can be reduced to 2.5mg/dose.

Trial Locations (17)

37232

Vanderbilt University, Nashville

55455

University of Minnesota, Minneapolis

T2N 4Z6

University of Calgary, Calgary

T5H 3V9

Alberta Health Services - Royal Alexandra Hospital, Edmonton

Royal Alexandra Hospital, Edmonton

T4N 4E7

Red Deer Regional Hospital, Red Deer

V8R 4R2

Victoria Cardiac Arrythmia Trials, Victoria

R2H 2A6

St. Boniface General Hospital, St. Boniface

E2L 4L2

New Brunswick Heart Centre, Saint John

B3H 3A6

Queen E II Health Sciences Centre, Halifax

L8L 2X2

Hamilton Health Sciences, Hamilton

K1Y 4W7

University of Ottawa Heart Institute, Ottawa

H4J 1C5

Hopital Sacre Coeur de Montreal, Montreal

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke

S4P 0W5

Prairie Vascular Research Network/Regina General Hospital, Regina

S7K 3H1

Saskatoon Cardiology Consultants/Royal University Hospital, Saskatoon

93-005

Medical University of Lodz, Lodz

All Listed Sponsors
collaborator

Vanderbilt University

OTHER

lead

Dr. Bob Sheldon

OTHER