92
Participants
Start Date
November 30, 2011
Primary Completion Date
December 31, 2014
Study Completion Date
March 31, 2015
Phenytoin
Phenytoin will be loaded using at total dose of 15mg/kg (rounded to the nearest 100mg) divided into three equal doses given once daily for 3 days.This will be followed by a daily maintenance dose of 4mg/kg once a day (rounded up to the nearest 50mg, with a maximum dose of 300mg)for 13 weeks.Phenytoin levels will be taken at 1 and 3 months.
Placebo
placebo identical in appearance to active IMP (phenytoin)
National Hospital for Neurology and Neurosurgery, London
Royal Hallamshire Hospital, Sheffield
National Multiple Sclerosis Society
OTHER
Multiple Sclerosis Society of Great Britain and Northern Ireland
UNKNOWN
University College, London
OTHER