Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation

PHASE3CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

June 30, 2013

Study Completion Date

August 31, 2013

Conditions
Graft FailureIschemia-reperfusion Injury
Interventions
DRUG

Heme arginate (Normosang)

3mg/kg as a single IV infusion prior to transplant over 30 mins and same dose repeated on day 2 post-transplantation. Each drug infusion will be followed by 100ml saline IV to flush the line.

DRUG

0.9% sodium chloride

Solution for infusion, this will be given prior to transplantation and again on day 2; the same as active drug.

Trial Locations (1)

EH16 4TJ

Royal Infirmary of Edinburgh/ University of Edinburgh, Edinburgh

All Listed Sponsors
collaborator

NHS Lothian

OTHER_GOV

lead

University of Edinburgh

OTHER

NCT01430156 - Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation | Biotech Hunter | Biotech Hunter