Bioavailability of Vagantin® Coated Tablets Relative to an Oral Methantheline Bromide Solution

blood sampling before and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 16 hours after administration of study medication

administration of 2 coated tablets Vagantin® (coated tablets of 50 mg methantheline bromide)

administration 100 ml methantheline solution (100 mg methantheline bromide)

"Volume of salivary gland secretion was measured by chewing a 5 x 5 cm piece of PARAFILM M® (American Can Company, UK) for 5 min. Saliva was collected in glass tubes and the amount of the stimulated saliva was measured by weighing"

Accommodation was measured with the optometer according to Schober (Velhagen 1972)

Pupil function was assessed with the pupillograph (Compact Integrated Pupillograph, AMTech, Weinheim, Germany). The following data were obtained: pupil diameter, response to defined flash stimuli