269
Participants
Start Date
October 31, 2011
Primary Completion Date
November 30, 2017
Study Completion Date
November 30, 2017
Sertraline + Olanzapine
Olanzapine 15mg/day. Adjustment of dose to 5mg/day to a maximum of 20mg/day will be permitted if necessitated by significant side-effects or clinical worsening
Sertraline + Placebo
Taper from current dose of olanzapine to placebo over 4 weeks. Continue placebo for remainder of 36 week study.
George Alexopoulos, MD, White Plains
Ellen Whyte, MD, Pittsburgh
Anthony Rothschild, MD, Worcester
Alastair Flint, MD, Toronto
University of Toronto
OTHER
University of Massachusetts, Worcester
OTHER
University of Pittsburgh
OTHER
Weill Medical College of Cornell University
OTHER