Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck

PHASE3CompletedINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

September 30, 2011

Primary Completion Date

November 30, 2020

Study Completion Date

May 31, 2021

Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
DRUG

AFATINIB

AFATINIBat the dose of 40 mg/during the 1st month and then 50 mg/d during the 11 following months

DRUG

Placebo of AFATINIB

placebo of Afatinib at the dose of 40 mg/during the 1st month and then 50 mg/d during the 11 following months

Trial Locations (26)

14076

Centre François Baclesse, Caen

26000

Centre de Radiothérapie Marie Curie, Valence

29609

CHRU Brest - Hôpital Morvan, Brest

31076

Clinique Pasteur Bâtiment l'Atrium, Toulouse

33075

CHU Bordeaux - Hôpital Saint-André, Bordeaux

33300

Polyclinique de Bordeaux Nord, Bordeaux

37044

CHU TOURS (Hôpital Bretonneau), Tours

42270

Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez

44229

Centre Eugène Marquis, Rennes

44600

Pôle Hospitalier Mutualiste- Centre Etienne Dolet, Saint-Nazaire

44805

Institut de Cancérologie de l'Ouest, Saint-Herblain

49933

Centre Paul Papin, Angers

56100

Centre Hospitalier Bretagne Sud, Lorient

67000

Strasbourg Oncologie Libérale, Strasbourg

69373

Centre Léon Bérard, Lyon

71000

Institut Claudius Regaud, Toulouse

74203

Hopitaux du Léman, Thonon-les-Bains

76038

Centre Henri Becquerel, Rouen

76600

Centre Guillaume le Conquérant, Le Havre

84000

Institut Sainte-Catherine, Avignon

86021

CHU Poitiers, Poitiers

94010

CHIC Créteil, Créteil

94805

Institut Gustave Roussy, Villejuif

13386 Cedex

AP-HM La Timone Adultes, Marseille

06189

Centre Antoine Lacassagne, Nice

54519 cedex

Institut de Cancérologie de lorraine (ICL), Vandœuvre-lès-Nancy

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Boehringer Ingelheim

INDUSTRY

lead

Centre Leon Berard

OTHER