Study of Ruxolitinib in Pancreatic Cancer Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

136

Participants

Timeline

Start Date

July 31, 2011

Primary Completion Date

June 30, 2013

Study Completion Date

November 30, 2016

Conditions
Pancreatic Cancer
Interventions
DRUG

Capecitabine

Capecitabine starting dose - 2000 mg/m\^2 (1000 mg/m\^2 twice a day (BID)) (NOTE: Frequency of administration may be adjusted during the study.)

DRUG

Ruxolitinib

Ruxolitinib starting dose - 15 mg BID (NOTE: Starting dose of randomized study drug may be 10 mg BID based on results from safety run-in study. Dose of ruxolitinib may be increased during randomized study.)

DRUG

Placebo

Placebo matching ruxolitinib

Trial Locations (39)

Unknown

Birmingham

Hot Springs

Burbank

Los Angeles

Santa Monica

Denver

Stamford

Boynton Beach

Fort Myers

St. Petersburg

Arlington Heights

Elks Grove Village

Indianapolis

Sioux City

Lexington

Louisville

Worcester

Ann Arbor

Detroit

Grand Rapids

Novi

Minneapolis

St Louis

Voorhees Township

Albuquerque

Lake Success

Durham

Hickory

Canton

Dayton

Tulsa

Bend

Portland

Danville

Pittsburgh

Knoxville

San Antonio

Richmond

Green Bay

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY