Safety and Immunogenicity of Novartis Meningococcal B Vaccine Formulated With OMV Manufactured at Two Different Sites, in Healthy Adolescents Aged 11-17 Years

PHASE3CompletedINTERVENTIONAL
Enrollment

344

Participants

Timeline

Start Date

August 31, 2011

Primary Completion Date

December 31, 2011

Study Completion Date

December 31, 2011

Conditions
Meningococcal DiseaseMeningococcal Meningitis
Interventions
BIOLOGICAL

Serogroup B meningococcal vaccine

"All subjects will receive two rMenB+OMV NZ vaccinations one month apart and will be followed for a total of 2 months. Subjects will be randomized to 1 of 2 treatment arms to receive either two doses of rMenB+OMV NZ vaccine Lot 1 or two doses of rMenB+OMV NZ Lot 2.~A total of 2 blood samples will be collected (at the first vaccination and 1 month after the 2nd vaccination). An additional blood draw will be collected in a subset of approximately 160 subjects (approximately 80 subjects in Group 1 and approximately 80 subjects in Group 2) at 2 weeks after the second vaccination"

Trial Locations (13)

3010

Murdoch Children's Research Institute-Level 5, 207 Bouverie St-University of Melbourne, Melbourne

4021

AusTrials Pty Ltd-Suites 6, 10 & 11, Peninsula Specialist Centre, Kippa-Ring

4029

Royal Children's Hospital, Herston

4075

AusTrials Pty Ltd-Suite 5, Level 1, 14 Primrose Street, Sherwood

5006

Women's and Children's Hospital, 72 King William Road, North Adelaide

6008

Telethon Institute for Child Heath Research-cnr, Hamilton Street and Roberts Road-Subiaco

V3R 8P8

TASC Research Services, 1-15243 91st Avenue, Surrey

B2N 1L2

Colchester Regional Hospital Colchester Research Group, 68 Robie Street, Truro

M9V 4B4

Albion Finch Medical Centre, 1620 Albion Road, Suite 106, Etobicoke

P3E 1H5

Medicor Research Inc, 359 Riverside, Suite 200, Greater Sudbury

L3Y 5G8

SKDS Research Inc, 221-679 Davis Dr.Newmarket, Toronto

M5G 1N8

Dr. Hartley Garfield Medicine Professional Corporation, 790 Bay Street, Suite 540, Toronto

N4S 5P5

Devonshire Clinical Research INC, 423 Devonshire Ave., Suite 301, Woodstock

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Vaccines

INDUSTRY

lead

Novartis

INDUSTRY

NCT01423084 - Safety and Immunogenicity of Novartis Meningococcal B Vaccine Formulated With OMV Manufactured at Two Different Sites, in Healthy Adolescents Aged 11-17 Years | Biotech Hunter | Biotech Hunter