1,522
Participants
Start Date
December 31, 2012
Primary Completion Date
August 31, 2015
Study Completion Date
June 30, 2016
Switching: Bupropion-SR
Bupropion-SR (Dose: 150 mg - 400 mg taken per day orally for up to 36 weeks): Initiating with bupropion-SR dose of 150 mg, then increasing dose per protocol up to 400 mg (200 mg BID), maintaining or decreasing dose for up to 36 weeks depending on response and side effect profile through the acute and continuation phases.
Augmenting: Antidepressant + Bupropion-SR
"Current antidepressant (either a SSRI or a SNRI or mirtazapine): Continue the dose prescribed at time of enrollment, or adjust depending on response or side effect profile for up to 36 weeks.~And~Bupropion-SR (Dose: 150 mg - 400 mg taken per day orally for up to 36 weeks): Initiating with bupropion-SR dose of 150 mg, then increasing dose per protocol up to 400 mg (200 mg BID), maintaining or decreasing dose for up to 36 weeks depending on response and side effect profile through the acute and continuation phases."
Augmenting: Antidepressant + Aripiprazole
"Current antidepressant (either a SSRI or a SNRI or mirtazapine): Continue the dose prescribed at time of enrollment or adjust depending on response or side effect profile for up to 36 weeks.~And~Aripiprazole (Dose: 2 mg - 15 mg taken orally once per day for up to 36 weeks): Initiating with aripiprazole dose of 2 mg for one week, then increasing dose per protocol up to 15 mg, maintaining or decreasing dose for up to 36 weeks depending on response and side effect profile through the acute and continuation phases."
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
Philadelphia VA Medical Center, Philadelphia, PA, Philadelphia
Washington DC VA Medical Center, Washington, DC, Washington D.C.
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore
Salem VA Medical Center, Salem, VA, Salem
Clarksburg Louis A. Johnson VA Medical Center, Clarksburg, WV, Clarksburg
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC, Salisbury
Asheville VA Medical Center, Asheville, NC, Asheville
Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur
Miami VA Healthcare System, Miami, FL, Miami
James A. Haley Veterans' Hospital, Tampa, FL, Tampa
Tuscaloosa VA Medical Center, Tuscaloosa, AL, Tuscaloosa
Memphis VA Medical Center, Memphis, TN, Memphis
Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
William S. Middleton Memorial Veterans Hospital, Madison, WI, Madison
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Kansas City VA Medical Center, Kansas City, MO, Kansas City
Central Texas Veterans Health Care System, Temple, TX, Temple
VA Eastern Colorado Health Care System, Denver, CO, Denver
Phoenix VA Health Care System, Phoenix, AZ, Phoenix
Southern Arizona VA Health Care System, Tucson, Tucson
VA Long Beach Healthcare System, Long Beach, CA, Long Beach
VA San Diego Healthcare System, San Diego, CA, San Diego
VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda
San Francisco VA Medical Center, San Francisco, CA, San Francisco
VA Puget Sound Health Care System American Lake Division, Tacoma, WA, Tacoma
VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven
Edward Hines Jr. VA Hospital, Hines, IL, Hines
Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha
New Mexico VA Health Care System, Albuquerque, NM, Albuquerque
Clement J. Zablocki VA Medical Center, Milwaukee, WI, Milwaukee
VA Office of Research and Development
FED