Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation

NACompletedINTERVENTIONAL
Enrollment

411

Participants

Timeline

Start Date

September 30, 2011

Primary Completion Date

May 31, 2021

Study Completion Date

June 30, 2021

Conditions
Heart FailureAtrial Fibrillation
Interventions
PROCEDURE

Rhythm control

Patients randomized to catheter ablation-based AF rhythm control group will receive optimal HF therapy and one or more aggressive catheter ablation, which include PV antral ablation and LA substrate ablation with or without adjunctive antiarrhythmic drug

OTHER

Rate Control

Patients in the rate control group will receive optimal HF therapy and rate control measures to achieve a resting HR \< 80 bpm and 6-minute walk HR \< 110 bpm.

Trial Locations (21)

100

National Taiwan University Hospital, Taipei

90620-001

Instituto de Cardiologia-FUC RS, Porto Alegre

T2N 2T9

Libin Cardiovascular Institute of Alberta, Calgary, Calgary

T5H 3V9

Royal Alexandra Hospital, Edmonton

V6Z 1Y6

Vancouver General, Vancouver

V8R 4R2

Royal Jubilee Hospital, Victoria

B3H 3A7

Queen Elizabeth II Health Science, Halifax

L8L 2X2

Hamilton Health Sciences Centre, Hamilton

K7L 2V7

Kingston General Hospital, Kingston

N2M 1B2

St. Mary's General Hospital, Kitchener

N6A 5A5

London Health Sciences Centre, London

L3Y 8C3

Southlake Regional Health Care, Newmarket

K1Y 4W7

University of Ottawa Heart Institute, Ottawa

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

Toronto General Hospital, University Health Network, Toronto

H1T 1C8

Institute de Cardiologie de Montréal, Montreal

H2L 4M1

CHUM Centre hospitalier universitaire de Montréal, Montreal

H3A 1A1

McGill University Health Centre, Montreal

G1V 4G5

Insitut universitaire de cardiologie and pneumologie de Quebec, Québec

J1H 5N4

CHUS Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke

S-171 76

Karolinska University Hospital, Stockholm

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Ottawa Heart Institute Research Corporation

OTHER

NCT01420393 - Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation | Biotech Hunter | Biotech Hunter