Safety of and Immune Response to a DNA HIV Vaccine Boosted With a Modified Vaccinia HIV Vaccine and Protein HIV Vaccine in Healthy Adults

PHASE1CompletedINTERVENTIONAL
Enrollment

184

Participants

Timeline

Start Date

December 19, 2011

Primary Completion Date

October 7, 2013

Study Completion Date

December 9, 2015

Conditions
HIV SeronegativityHIV Preventive Vaccine
Interventions
BIOLOGICAL

MVA-C + gp140/MF59

"SAAVI MVA-C administered as 0.5 ml intramuscularly in right deltoid, with placebo in left deltoid, at Month 0; SAAVI MVA-C administered as 0.5 ml intramuscularly in right deltoid at Month 1; Novartis subtype C gp140 admixed with Novartis MF59 adjuvant administered as 0.5 ml intramuscularly in left deltoid, with placebo in right deltoid, at Months 3, 6.~Placebo comparator: Placebo administered at Months 0, 1, 3, 6"

BIOLOGICAL

MVA-C + gp140/MF59

"SAAVI MVA-C administered as 0.5 ml intramuscularly in right deltoid, with Novartis subtype C gp140 admixed with Novartis MF59 adjuvant administered as 0.5 ml intramuscularly in left deltoid, at Months 0, 3; placebo in right deltoid at Month 1; placebo in each deltoid at Month 6~Placebo comparator: Placebo administered at Months 0, 1, 3, 6"

BIOLOGICAL

DNA-C2 + MVA-C

"SAAVI DNA-C2 administered as 1 ml intramuscularly in right deltoid, with placebo in left deltoid, at Month 0; SAAVI DNA-C2 administered as 1 ml intramuscularly in right deltoid at Month 1; SAAVI MVA-C administered as 0.5 ml intramuscularly in right deltoid, with placebo in left deltoid, at Months 3, 6~Placebo comparator: Placebo administered at Months 0, 1, 3, 6"

BIOLOGICAL

DNA-C2 + MVA-C + gp140/MF59

"SAAVI DNA-C2 administered as 1 ml intramuscularly in right deltoid, with placebo in left deltoid, at Month 0; SAAVI DNA-C2 administered as 1 ml intramuscularly in right deltoid at Month 1; SAAVI MVA-C administered as 0.5 ml intramuscularly in right deltoid at Months 3, 6; Novartis subtype C gp140 admixed with Novartis MF59 adjuvant administered as 0.5 ml intramuscularly in left deltoid, with placebo in right deltoid, at Months 3, 6~Placebo comparator: Placebo administered at Months 0, 1, 3, 6"

Trial Locations (3)

1864

Perinatal HIV Research Unit, Johannesburg

2570

Aurum Institute for Health Research, Klerksdorp

7750

Desmond Tutu HIV Centre, Cape Town

All Listed Sponsors
collaborator

South Africa AIDS Vaccine Initiative

NETWORK

lead

HIV Vaccine Trials Network

NETWORK

NCT01418235 - Safety of and Immune Response to a DNA HIV Vaccine Boosted With a Modified Vaccinia HIV Vaccine and Protein HIV Vaccine in Healthy Adults | Biotech Hunter | Biotech Hunter