Decreasing Postoperative Complications by Goal-Directed Fluid Therapy During Esophageal Resection

PHASE4CompletedINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

October 31, 2011

Primary Completion Date

October 31, 2015

Study Completion Date

October 31, 2015

Conditions
Esophageal Cancer
Interventions
OTHER

fluid optimisation

"Stroke Volume and Cardiac Index are measured with the Flotrac/Vigileo system and circulation is optimised~1. Crystalloid infusion (2,5 ml/kg/t) throughout surgery~2. 3 ml/kg Volulyte (synthetic colloid) is infused during 5 minutes and SV is measured directly before and 5 minutes after. If SV increases more than 10% the dose is repeated until no increase \> 10% is observed. A new dose is given if SV decreases more than 10% from the last value.~3. If despite optimal filling Cardiac Index (CI) is below 2,5 l/min/m2 infusion with dobutamin is started to attain CI \> 2,5.~4. If despite CI \> 2,5 Mean Arterial Pressure \<65 mmHg vasopressor (phenylephrine / norepinephrine) is started until MAP equals or is over 65."

Trial Locations (1)

58246

University Hospital Linkoeping, Linköping

All Listed Sponsors
lead

University Hospital, Linkoeping

OTHER

NCT01416077 - Decreasing Postoperative Complications by Goal-Directed Fluid Therapy During Esophageal Resection | Biotech Hunter | Biotech Hunter