Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

926

Participants

Timeline

Start Date

January 9, 2012

Primary Completion Date

July 9, 2021

Study Completion Date

July 9, 2021

Conditions
Cervical AdenocarcinomaCervical Adenosquamous CarcinomaCervical Squamous Cell Carcinoma, Not Otherwise SpecifiedStage IB Cervical Cancer AJCC v6 and v7Stage IIA Cervical Cancer AJCC v7Stage IIB Cervical Cancer AJCC v6 and v7Stage IIIB Cervical Cancer AJCC v6 and v7Stage IVA Cervical Cancer AJCC v6 and v7
Interventions
RADIATION

Brachytherapy

Undergo brachytherapy

DRUG

Carboplatin

Given IV

DRUG

Cisplatin

Given IV

RADIATION

External Beam Radiation Therapy

Undergo external beam radiation therapy

DRUG

Paclitaxel

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (326)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10021

Lenox Hill Hospital, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

10591

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow

10604

Memorial Sloan Kettering Westchester, Harrison

11030

North Shore University Hospital, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11203

State University of New York Downstate Medical Center, Brooklyn

11211

King Faisal Specialist Hospital and Research Centre, Riyadh

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11365

New York Hospital Medical Center of Queens, Fresh Meadows

11432

Queens Hospital Center, Jamaica

11501

NYU Winthrop Hospital, Mineola

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

11794

Stony Brook University Medical Center, Stony Brook

12208

Women's Cancer Care Associates LLC, Albany

14263

Roswell Park Cancer Institute, Buffalo

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

15213

UPMC-Magee Womens Hospital, Pittsburgh

15224

West Penn Hospital, Pittsburgh

15232

UPMC-Shadyside Hospital, Pittsburgh

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

19001

Abington Memorial Hospital, Abington

19102

Drexel University School of Medicine, Philadelphia

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

24016

Carilion Clinic Gynecological Oncology, Roanoke

27104

Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem

27157

Wake Forest University Health Sciences, Winston-Salem

27215

Cone Health Cancer Center at Alamance Regional, Burlington

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28025

Atrium Health Cabarrus/LCI-Concord, Concord

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28401

New Hanover Regional Medical Center/Zimmer Cancer Center, Wilmington

29303

Spartanburg Medical Center, Spartanburg

29341

Gibbs Cancer Center-Gaffney, Gaffney

29379

MGC Hematology Oncology-Union, Union

29425

Medical University of South Carolina, Charleston

29601

Saint Francis Hospital, Greenville

29621

AnMed Health Cancer Center, Anderson

29651

Gibbs Cancer Center-Pelham, Greer

30303

Grady Health System, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

31201

Central Georgia Gynecologic Oncology, Macon

32610

University of Florida Health Science Center - Gainesville, Gainesville

32806

Orlando Health Cancer Institute, Orlando

33136

Jackson Memorial Hospital-Holtz Children's Hospital, Miami

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

34239

Sarasota Memorial Hospital, Sarasota

35233

University of Alabama at Birmingham Cancer Center, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

39216

University of Mississippi Medical Center, Jackson

40202

Norton Hospital Pavilion and Medical Campus, Louisville

40241

Norton Brownsboro Hospital and Medical Campus, Louisville

40503

Baptist Health Lexington, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

43214

Riverside Methodist Hospital, Columbus

43614

University of Toledo, Toledo

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Health System - Akron Campus, Akron

45219

University of Cincinnati/Barrett Cancer Center, Cincinnati

45409

Miami Valley Hospital, Dayton

45429

Kettering Medical Center, Kettering

45433

Wright-Patterson Medical Center, Wright-Patterson Air Force Base

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46260

Saint Vincent Hospital and Health Care Center, Indianapolis

46321

The Community Hospital, Munster

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46545

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48106

Saint Joseph Mercy Hospital, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48912

Sparrow Hospital, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49503

Cancer Research Consortium of West Michigan NCORP, Grand Rapids

Mercy Health Saint Mary's, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

49684

Munson Medical Center, Traverse City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

53227

Aurora West Allis Medical Center, West Allis

53792

University of Wisconsin Hospital and Clinics, Madison

54311

Aurora BayCare Medical Center, Green Bay

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55102

United Hospital, Saint Paul

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55407

Abbott-Northwestern Hospital, Minneapolis

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

57701

Black Hills Obstetrics and Gynecology, Rapid City

Rapid City Regional Hospital, Rapid City

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59715

Bozeman Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60521

Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

Rush University Medical Center, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66160

University of Kansas Cancer Center, Kansas City

68114

Nebraska Methodist Hospital, Omaha

68198

University of Nebraska Medical Center, Omaha

70112

Louisiana State University Health Science Center, New Orleans

Tulane University Health Sciences Center, New Orleans

University Medical Center New Orleans, New Orleans

70121

Ochsner Medical Center Jefferson, New Orleans

70817

Woman's Hospital, Baton Rouge

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75246

Texas Oncology at Baylor Charles A Sammons Cancer Center, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76022

Texas Oncology Bedford, Bedford

76104

Texas Oncology - Fort Worth Cancer Center, Fort Worth

77030

Houston Methodist Hospital, Houston

M D Anderson Cancer Center, Houston

Memorial Hermann Texas Medical Center, Houston

77479

Houston Methodist Sugar Land Hospital, Sugar Land

78705

Texas Oncology-Austin Midtown, Austin

78731

Texas Oncology - Central Austin Cancer Center, Austin

78745

Texas Oncology - South Austin Cancer Center, Austin

79761

West Texas Cancer Center, Odessa

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80033

SCL Health Lutheran Medical Center, Wheat Ridge

80045

University of Colorado Hospital, Aurora

80111

Rocky Mountain Cancer Centers-Greenwood Village, Greenwood Village

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

Parker Adventist Hospital, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80210

Porter Adventist Hospital, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

SCL Health Saint Joseph Hospital, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

80222

Western States Cancer Research NCORP, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80301

Boulder Community Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

Southwest Oncology PC, Durango

82001

Cheyenne Regional Medical Center-West, Cheyenne

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84770

Dixie Medical Center Regional Cancer Center, St. George

85004

Cancer Center at Saint Joseph's, Phoenix

85012

Gynecologic Oncology Group of Arizona, Phoenix

85013

Saint Joseph's Hospital and Medical Center, Phoenix

85016

Arizona Oncology Associates-Biltmore Cancer Center, Phoenix

85704

Arizona Oncology Associates-West Orange Grove, Tucson

85710

Arizona Oncology Associates-Wilmot, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

87109

Lovelace Radiation Oncology, Albuquerque

88011

Memorial Medical Center - Las Cruces, Las Cruces

89169

Women's Cancer Center of Nevada, Las Vegas

91342

Olive View-University of California Los Angeles Medical Center, Sylmar

92868

Saint Joseph Hospital - Orange, Orange

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94010

Mills-Peninsula Medical Center, Burlingame

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View

94080

Kaiser Permanente-South San Francisco, South San Francisco

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

Kaiser Permanente-San Francisco, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94520

John Muir Medical Center-Concord Campus, Concord

94538

Kaiser Permanente-Fremont, Fremont

94589

Kaiser Permanente-Vallejo, Vallejo

Sutter Solano Medical Center/Cancer Center, Vallejo

94598

John Muir Medical Center-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94903

Kaiser Permanente-San Rafael, San Rafael

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95355

Memorial Medical Center, Modesto

95403

Sutter Pacific Medical Foundation, Santa Rosa

95602

Sutter Auburn Faith Hospital, Auburn

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95616

Sutter Davis Hospital, Davis

95661

Kaiser Permanente-Roseville, Roseville

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95687

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville

95816

Mercy Cancer Center - Sacramento, Sacramento

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96701

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96813

Queen's Medical Center, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97213

Providence Portland Medical Center, Portland

98001

MultiCare Auburn Medical Center, Auburn

98335

MultiCare Gig Harbor Medical Park, Gig Harbor

98372

MultiCare Good Samaritan Hospital, Puyallup

98405

MultiCare Tacoma General Hospital, Tacoma

99508

Alaska Women's Cancer Care, Anchorage

Providence Alaska Medical Center, Anchorage

119074

National University Hospital Singapore, Singapore

200032

Zhongshan Hospital Fudan University, Guangdong Province

06030

University of Connecticut, Farmington

06102

Hartford Hospital, Hartford

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

04102

Maine Medical Center-Bramhall Campus, Portland

04074

Maine Medical Center- Scarborough Campus, Scarborough

20889-5600

Walter Reed National Military Medical Center, Bethesda

01199

Baystate Medical Center, Springfield

01605

UMass Memorial Medical Center - Memorial Division, Worcester

03820

Wentworth-Douglass Hospital, Dover

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08103

Cooper Hospital University Medical Center, Camden

07601

Hackensack University Medical Center, Hackensack

07960

Morristown Medical Center, Morristown

08060

Virtua Memorial, Mount Holly

07753

Jersey Shore Medical Center, Neptune City

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

08043

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township

02905

Women and Infants Hospital, Providence

77555-0565

University of Texas Medical Branch, Galveston

77026-1967

Lyndon Baines Johnson General Hospital, Houston

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

N6A 4L6

London Regional Cancer Program, London

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

H2W 1S6

McGill University Department of Oncology, Montreal

H2X 3E4

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3H 2R9

The Research Institute of the McGill University Health Centre (MUHC), Montreal

S4T 7T1

Allan Blair Cancer Centre, Regina

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

GOG Foundation

NETWORK

NCT01414608 - Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer | Biotech Hunter | Biotech Hunter