44
Participants
Start Date
November 30, 2011
Primary Completion Date
July 31, 2013
Study Completion Date
July 31, 2014
Sitagliptin (DPP4 inhibitor)
Sitagliptin 200 mg (DPP4 inhibitor) or matching placebo will be given one hour prior to intra-arterial infusions
Substance P,
Substance P intra-brachial artery (2,4,8 pmol/min)
bradykinin
bradykinin intra-brachial artery (23.6, 47.2, and 94.3 pmol/min)
enalaprilat (ACE inhibitor)
intra-brachial artery(0.33 µg/min per 100 mL forearm volume)
Glucagon-like peptide 1
intra-brachial artery (0.45-3.60 pmol/min)
brain natriuretic peptide
Intra-brachial artery (0.90, 1.80 and 3.6 pmol/min)
Vanderbilt University- General Clinic Research Center, Nashville
Vanderbilt University
OTHER