Rotating Pazopanib and Everolimus to Avoid Resistance

PHASE2CompletedINTERVENTIONAL
Enrollment

101

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

April 30, 2014

Study Completion Date

April 30, 2014

Conditions
Clear Cell Renal Carcinoma
Interventions
DRUG

Pazopanib

Tablet 800mg qd til progression

DRUG

Everolimus

tablet 10 mg qd til progression

DRUG

Pazopanib

tablet 800mg qd, alternating schedule: 8 weeks Pazopanib, 8 weeks Everolimus

DRUG

Everolimus

tablet 10mg qd, alternating schedule: 8 weeks Pazopanib, 8 weeks Everolimus

DRUG

Everolimus

Everolimus 10mg qd monotherapy until second progression (PD per RECIST 1.1)when first progression after 8 weeks of Pazopanib in alternating regimen

DRUG

Pazopanib

Pazopanib 800mg qd monotherapy until second progression (PD per RECIST 1.1) when first progression after 8 weeks of Everolimus in alternating regimen

Trial Locations (17)

Unknown

St. Franciscus Gasthuis, Rotterdam

Medisch Centrum Alkmaar, Alkmaar

Acedemisch Medisch Centrum Amsterdam, Amsterdam

NKI-AVL, Amsterdam

Amphia ziekenhuis Breda, Breda

Maxima Medisch Centrum, Eindhoven

UMC Groningen, Groningen

Atrium Medisch Centrum Heerlen, Heerlen

Medische Centrum Leeuwarden, Leeuwarden

Acedemisch ziekenhuis Maastricht, Maastricht

St. Antonius ziekenhuis, Nieuwegein

Erasmus Medisch Centrum, Rotterdam

Orbis Medisch Centrum, Sittard-Geleen

Haga Ziekenhuis, The Hague

St. Elisabeth ziekenhuis, Tilburg

Isala klinieken, Zwolle

3508 GA

UMC Utrecht, Utrecht

All Listed Sponsors
lead

Netherlands Working Group on Immunotherapy of Oncology

OTHER

NCT01408004 - Rotating Pazopanib and Everolimus to Avoid Resistance | Biotech Hunter | Biotech Hunter