Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal Men

PHASE3CompletedINTERVENTIONAL
Enrollment

325

Participants

Timeline

Start Date

July 31, 2011

Primary Completion Date

September 30, 2013

Study Completion Date

September 30, 2013

Conditions
Male Hypogonadism
Interventions
DRUG

Oral testosterone undecanoate

Starting dose: 200 mg T (as TU) BID. Doses may be titrated up to a maximum dose of 300 mg T (as TU) BID or down to a minimum dose of 100 mg T (as TU) BID based on serum T values collected at 4-6 hours post AM dose on Days 30 and 60.

DRUG

topical testosterone gel

Starting dose: 5 g T applied once daily. Doses may be titrated up to a maximum dose of 10 g daily or down to a minimum dose of 2.5 g daily based on serum T values collected at 4-6 hours post AM dose on Days 30 and 60.

Trial Locations (30)

10016

University Urology Associates, New York

10577

Michael A. Werner, MD, PC, Purchase

11021

Bruce R. Gilbert, MD, PhD, Great Neck

11235

Maimonides Medical Center, Brooklyn

19004

Urologic Consultants of Southeast Pennsylvania, Bala-Cynwyd

21287

Johns Hopkins University, Baltimore

33180

South Florida Medical Research, Aventura

35040

Alabama Clinical Therapeutics, Calera

35235

Alabama Clinical Therapeutics, Inc., Birmingham

Alabama Internal Medicine, PC, Birmingham

35801

Medical Affliated Research Center, Inc., Huntsville

40202

University of Louisville, Louisville

75010

Research Across America, Carrollton

75234

Research Across America, Dallas

85712

Quality of Life Medical and Research Centers, LLC, Tucson

90048

Tower Urology, Los Angeles

90095

David Geffen School of Medicine, Los Angeles

90502

Harbor-UCLA Medical Center, LA Biomedical Research Institute, Torrance

91505

Providence Clinical Research, Burbank

92653

South Orange County Endocrinology, Laguna Hills

97504

Sunstone Medical Research, Medford

98195

University of Washington, Seattle

06762

Connecticut Clinical Research Center/ConnecTrials, Middlebury

06511

University of CT School of Medicine, New Haven

02118

Boston University School of Medicine, Boston

Unknown

University of Bonn, Clinic for Dermatology and Allergy, Bonn

University of Halle, Center for Reproduction and Androlgoy, Halle

Praxis Dr. Szymula, Leipzig

Praxis Dr. Schulze, Markkleeberg

University of Muenster, Center for Reproduction and Andrology, Münster

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

PharmaNet

INDUSTRY

collaborator

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

OTHER

lead

Clarus Therapeutics, Inc.

INDUSTRY

NCT01403116 - Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal Men | Biotech Hunter | Biotech Hunter