Use of Bubble Continuous Positive Airway Pressure Compared to Nasal Prong Oxygen or Humidified High Flow in Children Under Five With Severe Pneumonia and Hypoxaemia

NACompletedINTERVENTIONAL
Enrollment

975

Participants

Timeline

Start Date

July 31, 2011

Primary Completion Date

June 30, 2015

Study Completion Date

June 30, 2015

Conditions
PneumoniaHypoxaemia
Interventions
PROCEDURE

Bubble continuous positive airway pressure

All children will be monitored for by pulse oximetry for arterial O2 saturation, respiratory rate, lower chest wall in-drawing, intercostal retraction, head nodding, cyanosis, tracheal tug, heart failure (defined by the presence of tachypnea, tachycardia, gallop rhythm, hepatomegaly, pedal oedema, basal crackles). Arterial or capillary blood gas analyses will be done for children failing to maintain saturation (\>90% with allocated treatment), or if there is concern about hypercarbia or acidosis.

PROCEDURE

Humidified high flow air / O2 mix at 2 l/kg/min

Humidified high flow air / O2 mix at 2 l/kg/min through nasal canula. All children will be monitored for by pulse oximetry for arterial O2 saturation, respiratory rate, lower chest wall in-drawing, intercostal retraction, head nodding, cyanosis, tracheal tug, heart failure (defined by the presence of tachypnea, tachycardia, gallop rhythm, hepatomegaly, pedal oedema, basal crackles). Arterial or capillary blood gas analyses will be done for children failing to maintain saturation (\>90% with allocated treatment), or if there is concern about hypercarbia or acidosis.

PROCEDURE

Standard O2 supplementation by nasal cannula at 0.5 - 2 l/min

Standard O2 supplementation will be given by nasal cannula at 0.5 - 2 l/min. All children will be monitored for by pulse oximetry for arterial O2 saturation, respiratory rate, lower chest wall in-drawing, intercostal retraction, head nodding, cyanosis, tracheal tug, heart failure (defined by the presence of tachypnea, tachycardia, gallop rhythm, hepatomegaly, pedal oedema, basal crackles). Arterial or capillary blood gas analyses will be done for children failing to maintain saturation (\>90% with allocated treatment), or if there is concern about hypercarbia or acidosis.

Trial Locations (1)

1212

Dhaka Hospital, ICDDR,B, Dhaka

All Listed Sponsors
collaborator

AusAID

UNKNOWN

collaborator

University of Melbourne

OTHER

lead

International Centre for Diarrhoeal Disease Research, Bangladesh

OTHER

NCT01396759 - Use of Bubble Continuous Positive Airway Pressure Compared to Nasal Prong Oxygen or Humidified High Flow in Children Under Five With Severe Pneumonia and Hypoxaemia | Biotech Hunter | Biotech Hunter