Dasatinib Added to Gemcitabine for Subjects With Locally-advanced Pancreatic Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

June 30, 2011

Primary Completion Date

October 31, 2013

Study Completion Date

March 31, 2015

Conditions
Pancreatic Cancer
Interventions
DRUG

dasatinib

GEM 1000 mg/m2 by intravenous \[IV\] infusion weekly for 3 weeks of a 4-week cycle plus dasatinib 100 mg (or matched placebo) by mouth once daily (QD). Subjects will continue to receive study treatment until disease progression, unacceptable toxicity, withdrawal of consent, or study termination.

DRUG

Placebo

Matching Placebo

Trial Locations (74)

1090

Vienna

1097

Budapest

1122

Budapest

1200

Brussels

2148

Blacktown

2170

Liverpool

2485

Tweed Heads

3000

Leuven

3011

Footscray

3050

Parkville

3199

Frankston

7624

Pécs

9000

Ghent

9024

Győr

18015

Bethlehem

20133

Milan

20249

Hamburg

25030

Besançon

33100

Udine

33426

Boynton Beach

33606

Tampa

35249

Birmingham

42100

Reggio Emilia

42271

Saint-Priest-en-Jarez

42277

Saint-Priest-en-Jarez

49933

Angers

50937

Cologne

55455

Minneapolis

59037

Lille

60020

Ancona

63003

Clermont-Ferrand

67214

Wichita

69437

Lyon

72076

Tübingen

75674

Paris

76275

Zlín

77520

Olomouc

80045

Aurora

81925

München

87131

Albuquerque

90095

Los Angeles

92110

Clichy

92868

Orange

94115

San Francisco

115478

Moscow

200385

Craiova

350040

Krasnodar

394000

Voronezh

400015

Cluj-Napoca

420029

Kazan'

454087

Chelyabinsk

M4N 3M5

Toronto

M5G 2M9

Toronto

H2X 3J4

Montreal

532 03

Pardubice

180 81

Prague

Unknown

Dublin

58-506

Jelenia Góra

20-090

Lublin

10-228

Olsztyn

022328

Bucharest

HU16 5JQ

Hull

CM1 7ET

Chelmsford

ME16 9QQ

Maidstone

HA6 2RN

Northwood

SM2 5PT

Sutton

LS9 7TF

Leeds

EH4 2XU

Edinburgh

G12 OYN

Glasgow

L69 3GA

Liverpool

SW3 6JJ

London

W12 0HS

London

CH63 4JY

Metropolitan Borough of Wirral

SP2 8BJ

Salisbury

All Listed Sponsors
lead

Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

NCT01395017 - Dasatinib Added to Gemcitabine for Subjects With Locally-advanced Pancreatic Cancer | Biotech Hunter | Biotech Hunter