124
Participants
Start Date
October 18, 2011
Primary Completion Date
February 5, 2016
Study Completion Date
January 29, 2020
Bevacizumab
10 milligrams per kilogram every 2 weeks during the study for up to 12 cycles, each cycle length of 28 days
Radiotherapy
Total dose of 54 Grey (Gy) units delivered in 30 daily fractions of 1.8 Gy over 6 weeks during the chemoradiation phase.
Temozolomide (TMZ)
75 milligrams per square meter (mg/m\^2) daily continuous starting concomitantly with the first radiation fraction and ending with the last radiation fraction for a maximum number of treatment days = 49 days. During the TMZ adjuvant treatment phase and for participants from YPC: TMZ (150 to 200 mg/m\^2/day) x 12 cycles, 1st cycle 150 mg/m\^2/days 1-5, escalated to 200 mg/m\^2 on Days 1-5 from Cycle 2 onwards depending on the tolerance during the 1st cycle. Cycle length = 28 days.
Medizinische Universität Wien, Vienna
Semmelweis University, 2nd Dept of Pediatrics Neurooncology Unit, Budapest
Rigshospitalet; Onkologisk Klinik, København Ø
The Children's Hospital at Westmead, Westmead
UZ Leuven Gasthuisberg, Leuven
Kepler Universitätskliniken GmbH - Med Campus IV., Linz
Skejby Sygehus - Aarhus University Hospital; CF Center, Børneafdeling A, Aarhus N
Hopital Timone Enfants; Onco Pediatrie, Marseille
Fakultni Nemocnice V Motole, S.P., Prague
Istituto Giannina Gaslini-Ospedale Pediatrico IRCCS; U.O.S. Neuroncologia, Genoa
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Hopital Des Enfants; Service d Hemato-Oncologie, Toulouse
CHRU de Rennes - Hôpital Sud- Service d'Hématologie Pédiatrique, Rennes
Azienda Ospedaliera di Padova, Padua
CHRU de Tours - Centre de Pédiatrie Clocheville; Service d'Oncopédiatrie, Tours
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpigh, Bologna
Hopital Nord;Consult Pediatrie, Saint-Priest-en-Jarez
Hospital Universitario La Fe, Valencia
Centre Hospitalier d'Angers; Service de cancérologie pédiatrique, Angers
Hopital Brabois Enfants, Vandœuvre-lès-Nancy
Centre Oscar Lambret; Service de Pediatrie, Lille
Fakultni nemocnice Brno; 2. detska klinika, pracoviste Detska nemocnice, Brno
CHU ESTAING; Centre Regional de Cancérologie et Thérapie Cellulaire Pédiatrique (CRCTCP), Clermont-Ferrand
Hôpital Hautepierre, Strasbourg
Centre Leon Berard, Lyon
Institut Curie - Centre de Lutte Contre le Cancer (CLCC) de Paris; Service d Oncologie Pediatrique, Paris
Institut Gustave Roussy; Service Pediatrique, Villejuif
Lady Cilento Children's Hospital; Oncology Services Group, Level 12b, South Brisbane
Alberta Children'S Hospital, Calgary
Hospital For Sick Children, Toronto
Hopital Lenval; Service Hématologie Infantile, Nice
UMC St Radboud, Nijmegen
Erasmus Mc/Sophia's Childrens Hospital; Dept. of Pediatric Oncology, Rotterdam
Instytut Pomnik-Centrum Zdrowia Dziecka; Klinika Onkologii, Warsaw
Hospital Sant Joan De Deu, Esplugues de Llobregas
Hospital Universitari Vall d'Hebron, Barcelona
Sahlgrenska Universitetssjukhuset, Östra Sjukhus; Drottning Silvias Barnsjukhus, Gothenburg
Universitetssjukhuset Linköping; Barn och Ungdomskliniken, Linköping
Skånes Universitetssjukhus, Lund
Karolinska Universitetssjukhuset, Solna; Astrid Lindgrens Barnsjukhus, Barcanceravdelningen, Solna
Birmingham Childrens Hospital; Oncology Dept, Birmingham
Bristol Royal Hospital for Children; Paediatric Haematology, Oncology, BMT, Bristol
Addenbrookes Hospital; Paediatric Oncology Ward C2, Cambridge
Royal Hospital for Sick Children, Edinburgh
Leeds General Infirmary; Ward 35, Leeds
Alder Hey Children's NHS Foundation Trust, Liverpool
University College London NHS Foundation Trust, London
Great Ormond Street Hospital; Dept. Of Pediatric Oncology, London
Royal Manchester Childrens Hospital, Manchester
Newcastle University & The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne
Queens Medical Centre, Nottingham
Southampton General Hospital, Southampton
Royal Marsden Hospital; Pediatric Unit, Surrey
Hoffmann-La Roche
INDUSTRY