A Study of the Efficacy and Safety of Pregabalin as Add-On Therapy for Partial Onset Seizures in Children Ages 4-16 Years

PHASE3CompletedINTERVENTIONAL
Enrollment

295

Participants

Timeline

Start Date

September 27, 2011

Primary Completion Date

August 10, 2016

Study Completion Date

August 10, 2016

Conditions
Epilepsy, Partial Seizures
Interventions
DRUG

Pregabalin add-on therapy

Subjects will be randomized to receive a fixed dose of either placebo, pregabalin Level 1 (maximum 150 mg/day) or pregabalin Level 2 (maximum 600 mg/day) in a 1:1:1 ratio, in addition to the subjects current AED medication regimen. Either capsules or oral liquid form will be administered, depending on subjects preference and ability to swallow capsules, in two equally divided daily doses. The study will have an 8 week baseline period; a 2 week dose escalation period; a 9 week dose maintenance period; and a 1 week dose taper period.

DRUG

Pregabalin add-on therapy

Subjects will be randomized to receive a fixed dose of either placebo, pregabalin Level 1 (maximum 150 mg/day) or pregabalin Level 2 (maximum 600 mg/day) in a 1:1:1 ratio, in addition to the subjects current AED medication regimen. Either capsules or oral liquid form will be administered, depending on subjects preference and ability to swallow capsules, in two equally divided daily doses. The study will have an 8 week baseline period; a 2 week dose escalation period; a 9 week dose maintenance period; and a 1 week dose taper period.

DRUG

Pregabalin add-on therapy

Subjects will be randomized to receive a fixed dose of either placebo, pregabalin Level 1 (maximum 150 mg/day) or pregabalin Level 2 (maximum 600 mg/day) in a 1:1:1 ratio, in addition to the subjects current AED medication regimen. Either capsules or oral liquid form will be administered, depending on subjects preference and ability to swallow capsules, in two equally divided daily doses. The study will have an 8 week baseline period; a 2 week dose escalation period; a 9 week dose maintenance period; and a 1 week dose taper period.

Trial Locations (86)

1003

Center for Neurodiagnostic and Therapeutic Services, Sta Cruz

1008

University of Santo Tomas Hospital, Manila

1020

HUDERF, Brussels

1070

Cliniques Universitaires de Bruxelles Hôpital Erasme, Brussels

1100

Capitol Medical Center Inc., Quezon City

1102

St. Luke's Medical Center, Quezon City

1105

Philippine Children's Medical Center, Quezon City

1340

Centre Hospitalier Neurologique William Lennox, Ottignies

4000

UMBAL Sveti Georgi, Klinika po pediatria i genetichni zabolyavania, Plovdiv

6000

Cebu Doctors' University Hospital, Cebu City

Cebu Doctors' University Hospital, Cebu City

7623

Pécsi Tudományegyetem Klinikai Központ, Pécs

11000

Mother and Child Healthcare Institute Dr Vukan Cupic, Belgrade

University Children's Hospital Belgrade, Belgrade

11527

General Childrens Hospital of Athens P & A Kyriakou, Athens

15236

General Children's Hospital Penteli, Athens

21000

Institute for Child and Youth Healthcare of Vojvodina, Novi Sad

25316

NZOZ Centrum Neurologii Dzieciecej i Leczenia Padaczki, Kielce

27100

Fondazione Istituto Neurologico Nazionale Casimiro Mondino, IRCCS - Servizio di Farmacia, Pavia

Fondazione Istituto Neurologico Nazionale Casimiro Mondino, IRCCS, Pavia

27710

Duke Children's Hospital and Health Center, Durham

Duke Clinical Research Unit, Durham

30990

Paediatric Department, Ipoh

32308

Tallahassee Neurological Clinic, Tallahassee

32819

Pediatric Neurology, P.A., Orlando

33076

CHU Bordeaux - Hopital des Enfants, Bordeaux

33408

Laszlo J. Mate, M.D., P.A., North Palm Beach

33470

Axcess Medical Research, Loxahatchee Groves

34000

Clinical Center of Kragujevac, Kragujevac

34890

Marmara University Pendik Training and Research Hospital, Istanbul

35100

Ege University Medical Faculty Department of Pediatrics Health and Diseases, Izmir

35120

Izmir Tepecik Training and Research Hospital, Izmir

35210

Behcet Uz Children Disease and surgery Training and research hospital, Izmir

40202

Kosair Charities Pediatric Clinical, Louisville

Kosair Children's Hospital, Louisville

University of Louisville Physicians, Louisville

40536

Center for Clinical and Translational Science, Lexington

Kentucky Neuroscience Institute, Lexington

University of Kentucky Hospital Epilepsy Monitoring Unit, Lexington

University of Kentucky Hospital Pharmacy, UK Chandler Hosptial, Lexington

44308

Akron Children's Hospital, Akron

49027

"Komunalnyi zaklad Dnipropetrovska dytiacha miska klinichna likarnia", Dnipropetrovsk

49100

"Komunalnyi zaklad Dnipropetrovska oblasna dytiacha klinichna likarnia", Dnipropetrovsk

50139

Azienda Ospedaliero-Universitaria Meyer, Florence

50586

Hospital Kuala Lumpur, Kuala Lumpur

60123

A.O.U. Ospedali Riuniti di Ancona Presidio Ospedaliero G. Salesi, Ancona

61068

"Derzhavna ustanova Instytut nevrolohii, psykhiatrii ta narkolohii", Kharkiv

Derzhavna Ustanova Instytut Nevrolohii, Psykhiatrii ta Narkolohii NAMN Ukrainy,, Kharkiv

61080

Karadeniz Technical University Faculty of Medicine Farabi Hospital, Trabzon

65006

"Komunalna ustanova Odeskyi oblasnyi medychnyi tsentr psykhichnoho zdorovia,", Odesa

65031

"Komunalna ustanova Odeska oblasna dytiacha klinichna likarnia, Oblasnyi tsentr rannoi", Odesa

67098

Hopitaux Universitaires de Strasbourg - Hopital Hautepierre, Strasbourg

67513

"Komunalna ustanova Odeska oblasna psykhiatrychna likarnia 2,", S. Oleksandrivka

69677

Hôpital Mère Enfant, Bron

72202

Arkansas Children's Hospital, Little Rock

78258

Road Runner Research, Ltd., San Antonio

85718

Center for Neurosciences, Tucson

88018

Oblasnyi klinichnyi tsentr neirokhirurhii ta nevrolohii, viddilennia neirokhirurhii 2,, Uzhhorod

90027

Children's Hospital Los Angeles, Los Angeles

Children´s Hospital Los Angeles, Los Angeles

92380

Hopital Raymond Poincare, Garches

119074

National University Hospital, Singapore

229899

KK Women's and Children's Hospital, Singapore

300314

Centrul Medical Dr. Bacos Cosma, Timișoara

700309

"Spitalul Clinic de Urgente pentru Copii Sf. Maria,", Iași

3104802

Bnai Zion Medical Center, Haifa

08901

Saint Peter's University Hospital, New Brunswick

613 00

Fakultni nemocnice Brno - Detska nemocnice, Brno - Cerna Pole

150 06

Fakultni nemocnice v Motole, Prague

H-2660

Dr. Kenessey Albert Korhaz es Rendelointezet, Balassagyarmat

H-1023

Szent Janos Korhaz es Eszak Budai Egyesitett Korhazak, Budapest

H-1083

Semmelweis Egyetem, I. Sz. Gyermekgyogyaszati Klinika, Budapest

H-1089

Heim Pal Gyermekkorhaz, Neurologiai Osztaly, Budapest

H-1146

Magyarorszagi Reformatus Egyhaz Bethesda Gyermekkorhaz, Gyermekneurologia, Budapest

80-952

Klinika Neurologii Rozwojowej, Gdansk

31-503

Wojewodzki Specjalistyczny Szpital Dzieciecy im. sw. Ludwika w Krakowie, Krakow

60-355

Katedra i Klinika Neurologii Wieku Rozwojowego, Poznan

54-049

Oddzial Neurologii Dzieciecej, Dolnoslaski Szpital Specjalistyczny im.T. Marciniaka, Wroclaw

022102

Spitalul clinic de copii Dr. Victor Gomoiu, Bucharest

041914

"Spitalul Clinic de Psihiatrie Prof. Dr. Al. Obregia", Bucharest

550 082

Spitalul de Psihiatrie Dr. Ghe. Preda, Sibiu

06351

Samsung Medical Center/ Department of Pediatrics, Pediatric Neurology, Seoul

110-744

Seoul National University Hospital, Seoul

120 752

Severance Hospital, Yonsei University Health System, Seoul

06100

Hacettepe University Medical Faculty, Ankara

04209

"Derzhavnyi zaklad Ukrainskyi medychnyi tsentr reabilitatsii ditei z", Kyiv

All Listed Sponsors
lead

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

NCT01389596 - A Study of the Efficacy and Safety of Pregabalin as Add-On Therapy for Partial Onset Seizures in Children Ages 4-16 Years | Biotech Hunter | Biotech Hunter