NCT01388621 - Carboplatin-based Chemotherapy With or Without Panitumumab in Platinum-sensitive Recurrent Ovarian Cancer | Biotech Hunter

Enrollment

140

Participants

Timeline

Start Date

October 31, 2011

Primary Completion Date

July 31, 2014

Study Completion Date

July 31, 2015

Conditions

Ovarian Cancer

Interventions

DRUG

Panitumumab

Panitumumab 6 mg/kg/BW d1 + 15 q4w until progressive disease or for a max. of 6 cycles In case of CR, PR or SD at the end of the combination treatment in experimental arm, panitumumab monotherapy is to be continued with 9 mg/kg/BW d1 q3w until time of tumor progression or up to a maximum of 6 months.

DRUG

pegylated liposomal doxorubicin (PLD)

pegylated liposomal doxorubicin (PLD) 30 mg/m² d1 q4w until progressive disease or for a max. of 6 cycles

DRUG

Carboplatin

Carboplatin AUC 5 d1 q4w until progressive disease or for a max. of 6 cycles

DRUG

Gemcitabine

gemcitabine 1000 mg/m² d1 + 8 q3w until progressive disease or for a max. of 6 cycles

DRUG

Carboplatin

Carboplatin AUC 4 d1 q3w until progressive disease or for a max. of 6 cycles

DRUG

Panitumumab

Panitumumab 9 mg/kg/BW d1 q3w until progressive disease or for a max. of 6 cycles In case of CR, PR or SD at the end of the combination treatment in experimental arm, panitumumab monotherapy is to be continued with 9 mg/kg/BW d1 q3w until time of tumor progression or up to a maximum of 6 months.

Trial Locations (18)

10317

RECRUITING

Praxis Dr. Schilling / Till / Kohn FÄ f. Gynäkologie u. Geburtshilfe, Gynäkol.-Onkol. Schwerpunktpraxis, Berlin

10367

RECRUITING

Praxisklinik Frauenheilkunde, Berlin

12683

RECRUITING

Gynäkologische Praxis Dr. med. Ruhmland, Berlin

13086

RECRUITING

Park-Klinik Weißensee, Berlin

13125

WITHDRAWN

Helios Klinikum Berlin - Buch, Berlin

13353

RECRUITING

Frauenklinik Charité - Universitätsmedizin Berlin Campus Virchow-Klinikum, Berlin

13589

RECRUITING

Ev. Waldkrankenhaus Spandau, Berlin

15517

RECRUITING

Praxis Dr. Heinrich, Fürstenwalde

18059

WITHDRAWN

Universitätsfrauenklinik am Klinikum Südstadt, Rostock

20357

RECRUITING

Tagesklinik Altonaer Strasse, Hamburg

26789

RECRUITING

MVM mbH Onkologische Schwerpunktpraxis Leer, Leer

39130

RECRUITING

Klinikum Magdeburg, Magdeburg

53111

RECRUITING

Medizinisches Zentrum Bonn-Friedensplatz, Bonn

73557

RECRUITING

Stauferklinikum Schwäbisch Gmünd, Mutlangen

88045

RECRUITING

Praxis Dr. Oettle, Friedrichshafen

03048

RECRUITING

Carl-Thiem-Klinikum Cottbus Frauenklinik, Cottbus

09116

RECRUITING

Klinikum Chemnitz Frauen- und Kinderklinik, Chemnitz

06120

RECRUITING

Martin-Luther-Universität Halle-Wittenberg Zentrum für Frauenheilkunde und Geburtshilfe, Halle