A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis

PHASE4CompletedINTERVENTIONAL
Enrollment

351

Participants

Timeline

Start Date

July 26, 2011

Primary Completion Date

January 6, 2013

Study Completion Date

January 6, 2013

Conditions
Rheumatoid Arthritis
Interventions
DRUG

rituximab

1000 mg in 250 mL intravenous infusion

DRUG

methotrexate

10 to 25 mg/week (oral or parenteral)

DRUG

methylprednisolone

100 mg methylprednisolone administered by slow intravenous infusion at least 30 minutes prior to the start of each study drug infusion

DRUG

acetaminophen

1 gram acetaminophen administered orally 30 to 60 minutes prior to the start of each study drug infusion

DRUG

antihistamine

50 mg diphenhydramine hydrochloride or equivalent dose of alternate antihistamine administered orally 30 to 60 minutes prior to the start of each study drug infusion

Trial Locations (86)

10003

NYU Center for Musculoskeletal Care, New York

11201

Arthritis & Osteoporosis Center, Brooklyn

11787

Rheumatology Associates of Long Island, Smithtown

11803

Office of Premier Chatpar Md, Plainview

12203

The Center for Rheumatology, Albany

13210

Arthritis Health Associates; Clinical Research, Syracuse

14127

Buffalo Rheumatology Associates, Orchard Park

14618

Aair Research Center, Rochester

16635

Altoona Center For Clinical Research, Duncansville

18015

East Penn Rheumatology Associates, Pc, Bethlehem

18944

Pivotal Clinical Research, Llc, Perkasie

19090

Rheumatic Disease Associates; Clinical Research Unit, Willow Grove

19152

Arthritis Group, Philadelphia

19610

Clinical Research Center of Reading, Wyomissing

Pennsylvania Regional Center for Arthritis and Osteoporosis Research, Wyomissing

19713

Javed Rheumatology Associates, Inc., Newark

19958

Rheumatolgy Consultants of Deleware, Lewes

21502

Klein & Associates, M.D. P.A., Cumberland

21740

Klein & Associates, M.D., P.A., Hagerstown

22205

Arthritis Clinic of Northern Virginia, Arlington

27617

Shanahan Rheumatology & Immunology, PLLC, Raleigh

27834

Physicians East Pa, Greenville

28207

Arth&OsteoConsof theCarolinas-Charlotte, Charlotte

28210

Box Arthritis & Rheumatology, Charlotte

Carolina Bone & Joint P.A., Charlotte

29406

Low Country Rheumatology, PA, Charleston

29407

Rheumatology Associates, Charleston

30046

Parris & Associates, Lawrenceville

32174

Millenium Research, Ormond Beach

32746

Florida Arthritis Center, PI, Lake Mary

32804

Omega ResearchConsultants LLC, Orlando

33143

Center For Arthritis; Research Dept, South Miami

33180

Arthritis & Rheumatism; Disease Specialities, Aventura

33612

University of South Florida, Tampa

33613

Florida Medical Clinic; Clinical Research, Zephyrhills

34684

Arthritis Center Palm Harbor, Palm Harbor

Arthritis Rsrch of Florida, Inc., Palm Harbor

35294

Uni Of Alabama,Birmingham; Medicine - Rheumatology, Birmingham

35406

Clnical & Translational Reseach Center for Alabama, PC, Tuscaloosa

38119

Ramesh Gupta - PP, Memphis

38305

West Tennessee Research Institute, Jackson

38801

North Mississippi Med Clinics, Inc., Tupelo

39232

Arthritis and Osteoporosis; Treatment and Research Center, Flowood

Jackson Arthritis Clinic, Flowood

40515

Bluegrass Comm Research, Inc., Lexington

43203

CarePoint East, Columbus

44130

Paramount Medical Research, Middleburg Heights

44333

Crystal Arthritis Center, Inc., Akron

45402

Stat Research, Inc, Dayton

52401

Physician'S Clinic of Iowa, Cedar Rapids

53217

Rheumatic Disease Center, Glendale

55805

St. Luke's Hospital Association of Duluth, Duluth

61265

Quad City Rheumatology, Sc, Moline

63031

David S Rosenberg, Florissant

73069

LION Research, Norman

73103

Arthritis and Rheumatology; Center of Oklahoma PLLC, Oklahoma City

75150

Southwest Rheumatology, Mesquite

75246

Arthritis Centers of Texas, Dallas

78404

Adriana Pop-Moody MD Clinic PA, Corpus Christi

78758

Lovelace Scientific Resources Inc., Austin

79124

Amarillo Center For Clinical Research, Amarillo

80920

Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs, Colorado Springs

83404

Institute of Arthritis Research, Idaho Falls

83702

St. Luke's Intermountain Research Center, Boise

85027

Valley Arthritis Care, Phoenix

85234

ArthroCare, Arthritis Care; and Research P.C., Gilbert

85704

Catalina Pointe Rheumatology, Tucson

89502

Arthritis Center of Reno, Reno

90048

Medvin Clinical Research, Los Angeles

90606

Medvin Clinical Research, Whittier

91723

Medvin Clinical Research, Covina

91786

Inland Rheumatology; Clinical Trials, Inc., Upland

91942

Triwest Research Associates, La Mesa

92108

San Diego Arthritis Med Clnc, San Diego

92260

Desert Medical Advances; Rheumatology, Palm Desert

92563

Brigid Freyne-Private Practice; Internal Medicine, Rheum, Murrieta

93454

Pacific Arthritis Ctr Med Grp, Santa Maria

98133

Seattle Arthritis Clinic, Seattle

98405

Cedar Medical Center, Tacoma

99204

Arthritis Northwest, Spokane, Spokane

99336

Apex Clinical Research, Kennewick

80230-7127

Denver Arthritis Clinic, Denver

06606

Rheum & Internal Med Assoc-Bri, Bridgeport

06518

Arthritis & Osteoporosis Center Pc, Hamden

03756

Rheumatology Research Group, Lebanon

07666

Rheumatology Associates Of New Jersey, Teaneck

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01382940 - A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis | Biotech Hunter | Biotech Hunter