Estrogen Sensitivity and Ovulatory Dysfunction in Obesity

Subjects were instructed to apply 0.1 mg/d transdermal estrogen for one month.

Pituitary response was assessed to determine how estradiol administration alters pituitary sensitivity to GnRH.

Subjects who failed to initiate a menstrual period following 40 days on the patch were instructed to take 200 mg daily of progesterone for 10 days or as long as deemed necessary.