851
Participants
Start Date
October 31, 2011
Primary Completion Date
January 31, 2015
Study Completion Date
April 30, 2016
Atripla (r)
Patients are administered one tablet of Efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg (EFV/FTC/TDF, Atripla) to taken be taken orally once daily at bedtime without food.
Efavirenz
Participants will take one 600 mg tablet administered orally once daily without food.
Truvada
Participants will take one tablet of Emtricitabine 200mg/tenofovir disoproxil fumarate 300mg (FTC/TDF, Truvada) administered orally once daily with or without food.
Rifampin/isoniazid/pyrazinamide/ethambutol FDC
Participants will be administered Rifampin/isoniazid/pyrazinamide/ethambutol FDC tablets orally, once daily; dose by weight as determined in Table 5.1-1 of the protocol, for the first 8 weeks.
Rifampin/isoniazid FDC
Participants will be administered rifampin/isoniazid FDC tablets orally, once daily; dose by weight as determined in Table 5.1-1 in the protocol, for 16 weeks following the first 8 weeks.
Isoniazid
INH 300 mg orally once daily
CAPRISA eThekwini CRS, Durban
Les Centres GHESKIO CRS, Port-au-Prince
Walter Reed Project - Kenya Med. Research Institute Kericho CRS, Kericho
AMPATH at Moi Univ. Teaching Hosp. Eldoret CRS, Eldoret
BJ Medical College CRS, Pune
YRG CARE Medical Ctr., VHS Chennai CRS, Rajiv Gandhi Salai Taramani
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro
GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS, Port-au-Prince
College of Med. JHU CRS (30301), Blantyre
University of North Carolina Lilongwe CRS (12001), Lilongwe
San Miguel CRS, San Miguel
Wits HIV CRS, Johannesburg
Durban Adult HIV CRS, Durban
Soweto ACTG CRS (12301), Johannesburg
Joint Clinical Research Centre (JCRC) (12401), Kampala
Kalingalinga Clinic CRS (12801), Lusaka
UZ-Parirenyatwa CRS, AIDS Research Unit P.O. Box A178
Barranco CRS (11301), Lima
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NETWORK