Antiglucocorticoid Augmentation of antiDepressants in Depression

PHASE3CompletedINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

February 28, 2011

Primary Completion Date

February 28, 2013

Study Completion Date

June 30, 2013

Conditions
Depression
Interventions
DRUG

Metyrapone

500 milligrams to be taken twice a day orally

DRUG

placebo

a matched placebo will be administered to patients to take twice a day for 3 weeks

Trial Locations (11)

TS17 6SD

Stockton Affective Disorders Service, Newcastle upon Tyne

NE1 4LP

Newcastle Community Mental Health Team, Newcastle upon Tyne

Regional Affective Disorders Service, Newcastle upon Tyne

NE28 7PD

North Tyneside Community Mental Health Team, Newcastle upon Tyne

NE4 5PL

Newcastle Magnetic Resonance Centre, Newcastle upon Tyne

Unknown

Bradford District Care Trust, Bradford

Manchester Magnetic Resonance Centre, Manchester

LS12 3QE

Leeds Community Mental Health Team, Leeds

M13 9PT

Affective Disorders Service, Manchester

M30 0GT

Manchester Community Mental Health Team, Manchester

NE3 3XT

Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

lead

Jane Barnes

OTHER