A Study of Atezolizumab (an Engineered Anti-Programmed Death-Ligand 1 [PDL1] Antibody) to Evaluate Safety, Tolerability and Pharmacokinetics in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

661

Participants

Timeline

Start Date

June 21, 2011

Primary Completion Date

September 30, 2018

Study Completion Date

September 30, 2018

Conditions
TumorsHematologic Malignancies
Interventions
DRUG

Atezolizumab

Atezolizumab will be administered as IV infusion at eight dose levels (0.01, 0.03, 0.1, 0.3, 1, 3, 10, 20 mg/kg) in dose escalation cohort and at a dose which result in total drug exposure \</= exposures achieved at the MTD or MAD, will be selected for expansion cohort.

Trial Locations (21)

12206

New York Oncology Hematology, P.C., Albany

21231

Johns Hopkins Univ Med Center, Baltimore

23502

Virginia Oncology Associates, Norfolk

28078

Carolina BioOncology Institute; Can Therapy & Res Ctr, Huntersville

31059

Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse

33647

Moffitt Cancer Center, Tampa

37203

Sarah Cannon Research Inst., Nashville

37232

Vanderbilt, Nashville

60637

Uni of Chicago, Chicago

69008

Centre Leon Berard, Lyon

85258

HonorHealth Research Institute - Pima Center, Scottsdale

89169

Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas

90025

The Angeles Clinic, Los Angeles

94305

Stanford Univ Medical Center; Dept Central Pharmacy, Stanford

94805

Institut Gustave Roussy; Drct, Villejuif

06520

Yale Cancer Center, New Haven

02114

Massachusetts General Hospital., Boston

02215

Beth Israel Deaconess Med Ctr, Boston

Dana Farber Can Ins, Boston

08035

Hospital Universitari Vall d'Hebron, Barcelona

EC1A 7BE

Barts & London School of Med; Medical Oncology, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY