Ruxolitinib and Lenalidomide for Patients With Myelofibrosis

15 mg by mouth twice daily (BID), continuously in 28-day cycles.

5 mg by mouth each day on days 1-21, followed by 7 days of no therapy of each 28 day cycle.

"Prednisone will be added for patients who have not responded after 3 cycles of therapy.~30 mg by mouth a day during cycle 4, 15 mg/day during cycle 5, and 15 mg every other day during cycle 6, and then it will be discontinued."