Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B

PHASE3CompletedINTERVENTIONAL
Enrollment

201

Participants

Timeline

Start Date

November 30, 2012

Primary Completion Date

March 8, 2021

Study Completion Date

March 8, 2021

Conditions
Hepatitis B
Interventions
DRUG

Tenofovir

300 mg daily for 192 weeks (4 years)

DRUG

Peginterferon-alfa 2a and tenofovir

A combination of peginterferon-alfa 2a 180 µg weekly plus tenofovir 300 mg daily for 24 weeks and then only tenofovir 300 mg daily for 168 weeks (3.5 years).

Trial Locations (21)

20892

NIH Clinical Center, Bethesda

23498

Virginia Commonwealth University, Richmond

27599

University of North Carolina, Chapel Hill

27710

Duke University Medical Center, Durham

48109

University of Michigan Health System, Ann Arbor

55446

University of Minnesota, Plymouth

55905

Mayo Clinic, Rochester

63104

Saint Louis University, St Louis

63110

Washington University, St Louis

75246

Baylor University Medical Center, Dallas

75390

University of Texas Southwestern, Dallas

90048

Cedars Sinai Medical Center, Los Angeles

90095

University of California Los Angeles, Los Angeles

94115

California Pacific Medical Center, San Francisco

94143

University of California San Francisco, San Francisco

96813

Queen's Medical Center, Honolulu

98101

Virginia Mason Medical Center, Seattle

98105

University of Washington Medical Center, Seattle

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

M5T 2S8

University of Toronto-Toronto Western Hospital, Toronto

All Listed Sponsors
collaborator

University of Pittsburgh

OTHER

collaborator

National Center for Research Resources (NCRR)

NIH

lead

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

NCT01369212 - Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B | Biotech Hunter | Biotech Hunter