Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

1,151

Participants

Timeline

Start Date

April 30, 2012

Primary Completion Date

November 19, 2018

Study Completion Date

November 19, 2018

Conditions
Acute Ischemic StrokeDiabetesHyperglycemia
Interventions
DRUG

IV insulin to maintain target glucose concentration of 80-130 mg/dL

Intervention is to keep glucose concentration 80-130 mg/dL for up to 72 hours after randomization. IV insulin drip will be used to maintain glucose target.

DRUG

Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL

Sliding scale sub q insulin given will be given up to 4 times per day based on glucose concentration. It will be given only if glucose concentration greater than or equal to 180 mg/dL.

Trial Locations (70)

10029

The Mount Sinai Medical Center, New York

10032

Columbia University Medical Center, New York

10065

Weill Cornell Medical Center, New York

10451

Lincoln Medical and Mental Health Center, The Bronx

11203

Kings County Hospital, Brooklyn

SUNY Downstate University Hospital of Brooklyn, Brooklyn

11219

Maimonides Medical Center, New York

14210

Buffalo General Medical Center, Buffalo

15212

Allegheny General Hospital, Pittsburgh

15213

UPMC Presbyterian, Pittsburgh

15219

UPMC - Mercy, Pittsburgh

17033

Penn State Hershey Medical Center, Hershey

17403

WellSpan York Hospital, York

19001

Abington Memorial Hospital, Abington

19102

Thomas Jefferson University Hospital, Philadelphia

19104

Hospital of the University of Pennsylvania, Philadelphia

19140

Temple University Hospital, Philadelphia

20010

MedStar Washington Hospital Center, Washington D.C.

21201

University of Maryland Medical Center, Baltimore

22908

University of Virginia, Charlottesville

23298

Virginia Commonwealth University, Richmond

26506

West Virginia University, Morgantown

30308

Emory University Hospital - Midtown, Atlanta

30322

Emory University Hospital, Atlanta

Grady Memorial Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

32224

Mayo Clinic Jacksonville, Jacksonville

33136

Jackson Memorial Hospital, Miami

37205

St. Thomas Neuroscience Research Institute, Nashville

37232

Vanderbilt University Medical Center, Nashville

40506

University of Kentucky, Lexington

43210

Wexner Medical Center, Columbus

44307

Summa Akron City Hospital, Akron

45221

University of Cincinnati, Cincinnati

45409

Miami Valley Hospital, Dayton

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48085

William Beaumont Hospital-Troy, Troy

48109

University of Michigan, Ann Arbor

48201

Detroit Receiving Hospital, Detroit

48202

Henry Ford Health System, Detroit

48235

Sinai-Grace Hospital, Detroit

52242

University of Iowa Hospitals & Clinics, Iowa City

53226

Froedtert Memorial Hospital, Milwaukee

55415

Hennepin County Medical Center, Minneapolis

55455

University of Minnesota Medical Center, Fairview, Minneapolis

60611

Northwestern Memorial Hospital, Chicago

61637

OSF Saint Francis Medical Center, Peoria

66160

University of Kansas Medical Center, Kansas City

75390

UT Southwestern-Parkland Memorial Hospital, Dallas

UT Southwestern-Zale Lipshy University Hospital, Dallas

77030

Baylor College of Medicine, Houston

Memorial Herman Hospital, Houston

78552

Valley Baptist Medical Center, Harlingen

78701

Dell Seton Medical Center at UT, Austin

78705

Seton Medical Center, Austin

84132

University of Utah, Salt Lake City

85713

University of Arizona Medical Center - South Campus, Tucson

85724

University of Arizona, Tucson

90095

Ronald Regan Medical Center, Los Angeles

90806

Long Beach Memorial Medical Center, Long Beach

94110

San Francisco General Hospital, San Francisco

94114

California Pacific Medical Center - Davies Campus, San Francisco

California Pacific Medical Center-Pacific Campus, San Francisco

94117

UCSF Medical Center, San Francisco

94305

Stanford University Medical Center, Stanford

98104

Harborview Medical Center, Seattle

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital, Boston

08818

JFK Medical Center, Edison

07601

Hackensack University Medical Center, Hackensack

All Listed Sponsors
collaborator

Neurological Emergencies Treatment Trials Network (NETT)

NETWORK

collaborator

Medical University of South Carolina

OTHER

collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

University of Virginia

OTHER

NCT01369069 - Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial | Biotech Hunter | Biotech Hunter