Study to Assess the PK of Ketorolac Tromethamine Intranasal and to Assess the Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine

PHASE1CompletedINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

January 31, 2007

Primary Completion Date

March 31, 2007

Study Completion Date

February 29, 2008

Conditions
Assess Pharmacokinetics of Ketorolac Tromethamine Intranasal and Assess Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
Interventions
DRUG

Ketorolac tromethamine

30 mg of intranasal ketorolac tromethamine (one 100 µL spray into each nostril of a 15%, pH 7.2 solution)

DRUG

Oxymetazoline hydrochloride

Single intranasal dose of oxymetazoline hydrochloride (Afrazine®) (3 sprays of a 0.05% solution into each nostril) followed 30 minutes later by 30 mg of intranasal ketorolac tromethamine (one 100 µL spray into each nostril of a 15%, pH 7.2 solution)

Trial Locations (1)

Unknown

ICON Development Solutions, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Egalet Ltd

INDUSTRY