AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

99

Participants

Timeline

Start Date

September 21, 2011

Primary Completion Date

January 1, 2027

Study Completion Date

January 1, 2032

Conditions
Neurofibromatosis 1Neurofibromatosis Type 1NF1Neurofibroma, Plexiform
Interventions
DRUG

AZD6244

AZD6244 orally (at recommended Ph2 dose) every 12 hours on continuous daily schedule for cycles of 28 days until unacceptable toxicity, patient withdrawal or PD

Trial Locations (4)

19104

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

20892

National Institutes of Health Clinical Center, Bethesda

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01362803 - AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors | Biotech Hunter | Biotech Hunter