Antiangiogenic Therapy for Children with Recurrent Medulloblastoma, Ependymoma and ATRT

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

April 30, 2014

Primary Completion Date

April 30, 2030

Study Completion Date

April 30, 2030

Conditions
Medulloblastoma RecurrentEpendymoma RecurrentATRT Recurrent
Interventions
DRUG

Bevacizumab

10mg/kg, intravenous (iv), biweekly, 1 year

DRUG

Thalidomide

3mg/kg, oral, daily, 1 year

DRUG

Celecoxib

50-400mg, oral bid, daily, 1 year

DRUG

Fenofibric acid

90mg/m2, oral, daily, 1 year

DRUG

Etoposide

35-50 mg/m2, oral, alternating 21-day cycles of daily oral etoposide and cyclophosphamide, 1 year

DRUG

Cyclophosphamide

2.5mg/kg, oral, alternating 21-day cycles of daily oral etoposide and cyclophosphamide, 1 year

DRUG

Etoposide phosphate

0.5mg, intrathecal, day 1-5, every four weeks, alternating with intrathecal liposomal cytarabine, 1 year

DRUG

Cytarabine

16-30mg, intrathecal, twice weekly for two weeks out of every four weeks, alternating with intrathecal etoposide phosphate, 1 year

Trial Locations (22)

1090

RECRUITING

Medical University of Vienna, Vienna

2100

RECRUITING

University hospital Rigshospitalet, Copenhagen

4020

RECRUITING

Kepler Universitätsklinikum Med Campus IV, Linz

5020

RECRUITING

Salzburger Universitätsklinikum, Salzburg

5021

RECRUITING

Onkologisk-hematologisk seksjon Barneklinikken Haukeland universitetssjukehus, Bergen

6020

RECRUITING

Medical University of Innsbruck, Innsbruck

8036

RECRUITING

Medical University of Graz, Graz

15006

RECRUITING

Motol University Hospital Prague, Prague

28009

RECRUITING

Hospital Infantil Universitario Nino Jesus, Madrid

48503

RECRUITING

Helen DeVos Children's Hospital, Grand Rapids

59037

TERMINATED

Centre Oscar Lambret, Lille

61300

RECRUITING

University Hospital Brno, Brno

69373

RECRUITING

Centre Léon Bérard, Lyon

78723

RECRUITING

Dell Children's Medical Group SFC-HEM/ONC, Austin

60611-2605

TERMINATED

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

02215

TERMINATED

Dana-Farber Cancer Institute and Boston Children's Hospital, Boston

416 85

RECRUITING

Sahlgrenska Universitetssjukhuset, Gothenburg

581 85

RECRUITING

Universitetssjukhuset Linköping, Linköping

221 85

RECRUITING

Skånes universitetssjukhus, Lund

SE-171 76

RECRUITING

Karolinska University Hospital, Stockholm

901 85

RECRUITING

Norrlands Universitetssjukhus, Umeå

751 85

RECRUITING

Akademiska sjukhuset, Uppsala

All Listed Sponsors
lead

Medical University of Vienna

OTHER

NCT01356290 - Antiangiogenic Therapy for Children with Recurrent Medulloblastoma, Ependymoma and ATRT | Biotech Hunter | Biotech Hunter