A Study of Bevacizumab in Combination With Standard of Care Treatment in Participants With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)

PHASE3CompletedINTERVENTIONAL
Enrollment

485

Participants

Timeline

Start Date

June 25, 2011

Primary Completion Date

June 25, 2016

Study Completion Date

June 25, 2016

Conditions
Non-Squamous Non-Small Cell Lung Cancer
Interventions
DRUG

Bevacizumab

Participants will receive bevacizumab 7.5 or 15 milligrams per kilogram (mg/kg) intravenously.

DRUG

Docetaxel

Docetaxel 60 or 75 milligram per meter square (mg/m\^2) on Day 1 every 21 days.

DRUG

Erlotinib

Erlotinib 150 mg daily taken on an empty stomach at least one hour before or two hours after the ingestion of food.

DRUG

Pemetrexed

Pemetrexed 500 mg/m\^2 IV over 10 minutes on Day 1 every 21 days.

Trial Locations (179)

1090

Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie, Vienna

1130

Krankenhaus Der Stadt Wien Lainz; V. Medizinische Abt., Vienna

1140

SMZ - Baumgartner Hohe, Pavilion Leopold; 1.Interne Lungenabteilung, Onkologische Tagesklinik, Vienna

1180

Clin. Europe (Ste Elisabeth), Brussels

3010

Hospital General Univ. de Alicante; Servicio de Oncologia, Alicante

3400

Nordsjællands Hospital, Hillerød, Onkologisk Afdeling, Hillerød

4400

A.Ö. LKH; Abt. für Lungenkrankheiten, Steyr

4600

Klinikum Wels-Grieskirchen; Lungenabt., Wels

6020

Tiroler Landeskrankenanstalten Ges.M.B.H.; Innere Medizin Abt. Für Hämatologie & Onkologie, Innsbruck

6161

Lkh Natters; Abt. Für Atemwegs- & Lungenkrankheiten, Natters

6300

Centro Oncologico Infinito; Oncologia, La Pampa

6845

LKH Hohenems; Abteilung für Pulmologie, Hohenems

7600

Hospital Privado de Comunidad; Oncology, Mar del Plata

8500

Clínica Viedma, Viedma, Rio Negro

11527

Sotiria Hospital, Athens

13285

Hôpital Saint Joseph; Oncologie Medicale, Marseille

13617

Poly Parc Rambot La Provencale; Chimiotherapie Ambulatoire, Aix-en-Provence

13915

Hopital Nord; Service d'Oncologie Multidisciplinaire et Innovation Thérapeutique, Marseille

14076

Centre Francois Baclesse; Oncologie, Caen

14140

Hospital Central Sur de Alta Especialidad Petróleos Mexicanos, Mexico City

15258

Tawam Hospital; Medical Oncology Department, Al Ain City

16132

IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A, Genoa

16830

Hotel Dieu de France; Oncology, Beirut

18015

St. Lukes Hospital and Health Network, Bethlehem

18512

Hematology & Oncology Assoc; North Eastern Pennsylvania, Dunmore

19047

St. Mary Medical Center, Langhorne

19096

Lankenau Hospital, Wynnewood

19104

University of Pennsylvania; Radiation Oncology, Philadelphia

University of Pennsylvania, Philadelphia

19140

Temple University Hospital, Philadelphia

20230

Centenario Hospital Miguel Hidalgo, Aguascalientes

21047

Az. Osp. Di Busto P.O. Di Saronno; U.O. Di Oncologia Medica, Saronno

21401

Anne Arundel Health System Research Instit-Annapolis Oncology Ctr, Annapolis

22927

LungenClinic Großhansdorf, Großhansdorf

23704

Delta Hematology/ Oncology Associates, Portsmouth

24014

Blue Ridge Cancer Care - Roanoke, Roanoke

26121

Pius-Hospital; Klinik fuer Haematologie und Onkologie, Oldenburg

28033

Centro Oncologico MD Anderson International Espana, Madrid

28040

Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid

28046

Hospital Universitario La Paz; Servicio de Oncologia, Madrid

28602

Carolina Oncology Specialists, PA - Hickory, Hickory

30322

Emory Univ Winship Cancer Inst, Atlanta

31076

Clinique Pasteur; Pneumologie, Toulouse

31405

Summit Cancer Care PC, Savannah

32207

Baptist - MD Anderson Cancer Center, Jacksonville

32256

Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy), Jacksonville

32429

Johannes-Wesling-Klinikum Minden; Onkologische Ambulanz / Tagesklinik, Minden

32955

Cancer Care Centers of Brevard, Rockledge

33140

Mount Sinai Medical Center, Miami Beach

33428

Lynn Cancer Institute - West, Boca Raton

34376

Fachklinik für Lungenerkrankungen, Immenhausen

36688

USA Mitchell Cancer Institute, Mobile

37920

University of Tennessee Medical Center Cancer Institute, Knoxville

38138

West Clinic, Germantown

40245

Jewish Cancer Care, Louisville

40536

University of Kentucky Medical Center, Lexington

42271

Institut de Cancérologie de Loire, Saint-Priest-en-Jarez

43219

Mid Ohio Onc Hematology Inc, Columbus

43617

Toledo Hospital; CCOP Toledo, Toledo

44710

Aultman Hospital, Canton

44805

Ico Rene Gauducheau; Oncologie, Saint-Herblain

45042

Signal Point Clinical; Research Center, LLC, Middletown

45420

Dayton Clinical Oncology Prog, Dayton

46010

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia

46017

Hospital Universitario Dr. Peset; Servicio de Oncologia, Valencia

46237

St. Francis Medical Group, Indianapolis

47630

Oncology Hematology Associates of Southwest Indiana, Newburgh

48106

Ann Arbor Hematology Oncology, Ann Arbor

48202

Henry Ford Hospital; Hematology Oncology, Detroit

48903

Hospital de Cruces; Servicio de Oncologia, Barakaldo

49546

Cancer & Hematology Center of West Michigan, Grand Rapids

50009

Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza

50010

McFarland Clinic, Ames

51465

Praxis Dr. med. David Borquez, Bergisch Gladbach

53792

UNI OF WISCONSIN SCHOOL OF MEDICINE; GI Oncology Research Group, Paul P Carbone Cancer Center, Madison

54601

Gundersen Lutheran, La Crosse

54915

Fox Valley Hema and Onc SC, Appleton

55416

Metro-Minnesota CCOP, Saint Louis Park

56124

A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii, Pisa

57001

Diavalkaniko Hospital, Thessaloniki

59020

Centre Oscar Lambret, Lille

59037

Hopital Calmette; Pneumologie, Lille

60007

Alexian Brothers Neurosci Inst, Elk Grove Village

60201

Oncology-Evanston Nthwest Healthcare Kellogg Cancer Care Ctr, Evanston

60305

W. Suburban Ctr for Cncer Care, River Forest

60435

Joliet Oncology Hematology Associates, Ltd., Joliet

60488

Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie, Frankfurt

60714

Cancer Care & Hematology; Specialists of Chicagoland, Niles

63131

Heartland CCOP/Missouri Baptist Medical Center, St Louis

64507

St Joseph Oncology, Saint Joseph

66421

Universitaetsklinikum des Saarlandes; Innere Medizin V, Homburg/Saar

67065

Centre Paul Strauss; Oncologie Medicale, Strasbourg

69310

Ch Lyon Sud; Chir Onc Gyne Sct Jules Courmont, Pierre-Bénite

69394

Hopital Louis Pradel; Cardiologie B, Lyon

69400

Hopital Nord Ouest;Unite 2c, Gleizé

70014

Chi De La Haute Saone De Vesoul; Pneumologie, Vesoul

70508

Louisiana Oncology Associates, Lafayette

70809

Hematology/Oncology Clinic, LLP, Baton Rouge

72401

Clopton Clinic, Jonesboro

73730

Klinikum Esslingen; Klinik für Kardiologie, Angiologie und Pneumologie, Esslingen am Neckar

76137

St. Vincentius Kliniken Karlsruhe; Abteilung Hämatologie / Onkologie, Karlsruhe

80131

IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A, Napoli

80336

Ludwig-Maximilians Uni Klinik Innenstadt; Medizinische Klinik, München

83041

Hia Sainte Anne; Pneumologie, Toulon

83056

Hopital Sainte Musse; Pneumologie, Toulon

83100

Citta Ospedaliera; Divisione Oncologia Medica, Avellino

83854

Kootenai Cancer Center, Post Falls

85304

Palo Verde Hema/Onc, Glendale

85306

Arizona Center for Cancer Care, Glendale

90603

Innovative Clinical Research Institute, Whittier

91505

East Valley Hematology ; Oncology Medical Group, Burbank

92008

California Cancer Associates for Research & Excellence, Inc., Encinitas

93401

Coastal Integrative Cancer Care, San Luis Obispo

94010

Centre Hospitalier Intercommunal; Service de Pneumologie, Créteil

95300

CH Rene Dubos; Oncologie, Pontoise

95816

Sutter Cancer Center, Sacramento

97420

Bay Area Hospital, Coos Bay

99208

Medical Oncology Associates, Spokane

99437

Zentralklinik Bad Berka GmbH; Pneumologie, Bad Berka

92037-1027

Scripps Clinic; Hematology & Oncology, La Jolla

06050

The Hospital of Central CT, New Britain

06360

Eastern Ct Hema/Onco Assoc; Dept of Oncology, Norwich

67214-3728

Cancer Center of Kansas, Wichita

04074

New England Cancer Specialists, Scarborough

03909

York Hospital, York Village

02111

Tufts Medical Center; Neely Cancer Center, Boston

11794-9447

Stony Brook Univ Cancer Ctr; Medical Oncology Clinic, Stony Brook

02860

Memorial Hospital of Rhode Island, Pawtucket

75390-9015

Unv of TX SW Med Cntr; Hematology/Onc, Dallas

C1426ANZ

Inst. Alexander Fleming; Oncology Dept, Buenos Aires

S2000DSV

Sanatorio Parque de Rosario, Rosario

03000

ISIS Clinica Especializada, Santa Fe

60125-120

Centro de Pesquisa Clínica- Instituto do Câncer do Ceará- ICC, Fortaleza

40170-380

Nucleo de Oncologia da Bahia - NOB, Salvador, Bahia

70200-730

Sociedade beneficente de senhoras Hospital Sirio Libanes, Brasília

70390-150

Centro de Estudos e Pesquisas Oncologicas - CESPO, Brasília

72110-980

Instituto de Câncer de Brasília, Taguatinga

22793-080

Clinicas Oncologicas Integradas - COI, Rio de Janeiro

98700-000

Hospital de Caridade de Ijui; Oncologia, Ijuí

88301-220

Clinica de Neoplasias Litoral, Itajaí

01509-010

Hospital A. C. Camargo; Oncologia, São Paulo

CEP 01321-001

Hospital Sao Jose, São Paulo

06189

Centre Antoine Lacassagne, Nice

07548

SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie, Gera

06120

Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin I, Halle

04207

Robert-Koch-Klinik; Pneumologie, Leipzig

04357

Praxis Christian Geßner, Leipzig

185 47

Metropolitan Hospital; 2Nd Oncology Clinic, Piraeus

570 10

General Hospital of Thessaloniki Papanikolaou; Uni Pneumonology Dept., Thessaloniki

00128

Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica, Rome

00152

Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1, Rome

464-8681

Aichi Cancer Center Hospital; Respiratory Medicine, Aichi

277-8577

National Cancer Center Hospital East; Thoracic Oncology, Chiba

791-0280

National Hospital Organization Shikoku Cancer Center; Thoracic Oncology, Ehime

811-1395

National Hospital Organization Kyushu Cancer Center, Thoracic Oncology, Fukuoka

673-8553

Hyogo Cancer Center; Thoracic Oncology, Hyōgo

236-0051

Kanagawa Cardiovascular and Respiratory Center; Respiratory Medicine, Kanagawa

240-8555

Yokohama Municipal Citizen'S Hospital; Respiratory, Kanagawa

981-1293

Miyagi Cancer Center; Respiratory Medicine, Miyagi

700-8558

Okayama University Hospital; Respiratory and Allergy Medicine, Okayama

534-0021

OSAKA CITY GENERAL HOSPITAL;Medical Oncology, Osaka

541-8567

Osaka International Cancer Institute; Thoracic Oncology, Osaka

411-8777

Shizuoka Cancer Center; Thoracic Oncology, Shizuoka

104-0045

National Cancer Center Hospital; Thoracic Medical Oncology, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Respiratory Medicine, Tokyo

11-236

American University of Beirut - Medical Center, Beirut

Unknown

Middle East Inst. of Health; Oncology, Beirut

Centro Médico Abc the American British Cowdray Medical Center, I.A.P. - Centro de Cáncer, Mexico City

4818 CK

Amphia Ziekenhuis; Afdeling Longziekten, Breda

5623 EJ

Catharina Ziekenhuis; Dept of Lung Diseases, Eindhoven

3844 DG

Ziekenhuis St Jansdal; Dept of Lung Diseases, Harderwijk

6202 AZ

Academisch Ziekenhuis Maastricht, Maastricht

3435 CM

Antonius Ziekenhuis; Dept of Lung Diseases, Nieuwegein

2504 LN

Leyenburg Hospital; Pulmonology, The Hague

P.O Box 35

College of Medicine & Sciences, Sultan Qaboos University Hospital, Muscat

975 17

Fnsp Fdr Banska Bystrica; Dep of Pneumology&Ftizeology, Banská Bystrica

826 06

FNsP Bratislava, Nemocnica Ruzinov, Bratislava

04001

Vychodoslovensky onkologicky ustav, Košice

949 88

Inst. of Tb & Respiratory Diseases; Dep. of Oncology, Nitra

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01351415 - A Study of Bevacizumab in Combination With Standard of Care Treatment in Participants With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter