Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer

PHASE1TerminatedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

October 31, 2011

Primary Completion Date

December 31, 2015

Study Completion Date

December 31, 2015

Conditions
Advanced Cancer
Interventions
DRUG

PF-05212384

PF-05212384 intravenous infusion weekly starting at 110 mg.

DRUG

PD-0325901

PD-0325901 Oral twice daily (BID) dosing 2 mg BID 3 weeks on 1 week off

DRUG

PF-05212384

PF-05212384 intravenous infusion weekly starting at 95 mg.

DRUG

irinotecan

Irinotecan by intravenous infusion at 180 mg/m2 every two weeks (Q x 2 week)

Trial Locations (18)

20132

Ospedale San Raffaele, Milan

29406

MUSC Specialty Care-North, North Charleston

29425

Medical University of South Carolina, Hollings Cancer Center, Charleston

Medical University of South Carolina, Charleston

MUSC, Investigational Drug Services, Charleston

29464

MUSC Health East Cooper, Mt. Pleasant

80045

Anschutz Cancer Pavilion, Aurora

University of Colorado Denver (CTRC), Aurora

University of Colorado Hospital Anschutz Inpatient Pavilion, Aurora

University of Colorado Hospital, Aurora

90095

Ronald Reagan UCLA Medical Center, Los Angeles

UCLA Medical Center, Los Angeles

UCLA Oncology Center, Los Angeles

90404

Santa Monica - UCLA Medical Center and Orthopaedic Hospital, Santa Monica

UCLA Santa Monica Hematology Oncology, Santa Monica

90095-6984

Ronald Reagan UCLA Medical Center, Los Angeles

M5G 2M9

Princess Margaret Hospital, Toronto

08035

Hospital General Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT01347866 - Clinical Study Of PI3K/mTOR Inhibitors In Combination With An Oral MEK Inhibitor Or Irinotecan In Patients With Advanced Cancer | Biotech Hunter | Biotech Hunter