127
Participants
Start Date
August 31, 2011
Primary Completion Date
March 31, 2018
Study Completion Date
March 31, 2018
Cyclophosphamide
Days -6 and -5: 14.5 mg/kg/day IV. Days 3 and 4: 50 mg/kg/day IV.
Fludarabine
Days -6, -5, -4, -3, and -2: 30 mg/m\^2/day IV.
Total body irradiation
Day -1: 200 centigray in one fraction.
Mycophenolate Mofetil
Days 5 to 35: 15 mg/kg PO three times per day; max daily dose 1 g.
Tacrolimus 60
Begin dosing at 1 mg IV daily on Day 5. Dose is titrated according to serum levels. Stop at Day 60.
Tacrolimus 90
Begin dosing at 1 mg IV daily on Day 5. Dose is titrated according to serum levels. Stop at Day 90.
Tacrolimus 120
Begin dosing at 1 mg IV daily on Day 5. Dose is titrated according to serum levels. Stop at Day 120.
Bone marrow transplant
Donor stem cells infused IV on Day 0.
Sidney Kimmel Comprehensive Cancer Center, Baltimore
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
OTHER