1,401
Participants
Start Date
July 6, 2011
Primary Completion Date
February 1, 2016
Study Completion Date
July 30, 2021
Obinutuzumab
Obinutuzumab 1000 milligrams (mg) intravenous (IV) infusion will be administered on Day 1, 8, and 15 of Cycle 1 and then on Day 1 of each subsequent cycle during induction period and obinutuzumab 1000 mg IV infusion every 2 months during maintenance period.
Cyclophosphamide
Cyclophosphamide 750 mg/m\^2 IV will be administered on Day 1 of each cycle during induction period.
Doxorubicin
Doxorubicin 50 mg/m\^2 IV will be administered on Day 1 of each cycle during induction period.
Vincristine
Vincristine 1.4 mg/m\^2 (maximum 2 mg) IV will be administered on Day 1 of each cycle during induction period.
Prednisone
Prednisone 100 mg (or equivalent prednisolone or methylprednisolone) will be administered orally on Days 1-5 of each cycle during induction period.
Bendamustine
Bendamustine 90 mg/m\^2 IV infusion will be administered on Days 1 and 2 of each cycle during induction period.
Rituximab
Rituximab 375 milligrams per square meter (mg/m\^2) IV infusion will be administered on Day 1 of each cycle during induction period and rituximab 375 mg/m\^2 every 2 months during maintenance period.
National Taiwan Universtiy Hospital; Division of Hematology, Taipei
Chang Gung Medical Foundation - Linkou; Division of Hematology- Oncology, Taoyuan District
Semmelweis University, First Dept of Medicine, Budapest
National Institute of Oncology, A Dept of Internal Medicine, Budapest
Concord Repatriation General Hospital; Haematology, Sydney
Westmead Hospital; Haematology, Sydney
UZ Leuven Gasthuisberg, Leuven
Peter MacCallum Cancer Centre; Department of Haematology, Melbourne
St Vincent'S Hospital; Haematology, Fitzroy
Austin and Repatriation Medical Centre; Cancer Services, Melbourne
Monash Medical Centre; Haematology, Melbourne
University of Debrecen Medical and Health Science Center, Institute of Internal Medicine, Hematology, Debrecen
Princess Alexandra Hospital Woolloongabba; Clinical Hematology and Medical Oncology, Woolloongabba
Fiona Stanley Hospital, Murdoch
University of Szeged, II Dept of Internal Medicine, Szeged
AZ Groeninge, Kortrijk
UZ Gent, Ghent
Petz Aladar Megyei Korhaz; Hematologia, Győr
Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology, Taipei
Hopital De La Conception; Hematologie Clinique, Marseille
Onkologischer Schwerpunkt am Oskar-Helene-Heim; Dres. Herrenberger, Keitel-Wittig u. Kirsch, Berlin
Universitätsklinikum Greifswald Klinik für Innere Medizin C und Poliklinik, Greifswald
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia, Rozzano
Ospedale Maggiore Di Milano; U.O. Ematologia I - Padiglione Marcora, Milan
Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia, Milan
UKSH, Campus Kiel; Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Kiel
ASST PAPA GIOVANNI XXIII; Ematologia, Bergamo
Pius-Hospital; Klinik fuer Haematologie und Onkologie, Oldenburg
Hospital Univ. 12 de Octubre; Servicio de Hematologia, Madrid
Hospital Universitario la Paz; Servicio de Hematologia, Madrid
Fundacion Hospital de Alcorcon; Servicio de Hematologia, Alcorcón
Hopital Augustin Morvan; Hematologie, Brest
Onkologische Schwerpunktpraxis Dres. Bernd Gaede, Hans-Ulrich Ehlers, Ulrike Rodewig u.w., Hanover
Brüderkrankenhaus St. Josef, Paderborn
Hopital Saint Eloi; Hematologie Oncologie Medicale, Montpellier
Uni Degli Studi; Dip.Med.Clinica E Sperim. Ematologia, Padua
Uni Göttingen, Georg-August-Universität; Klinik für Hämatologie und Medizinische Onkologie, Göttingen
Onkologische Gemeinschaftspraxis, Magdeburg
Otto von Guericke Uni Magdeburg Uniklinik; Hämatologie/Onkologie, Magdeburg
St. Frankziskus Krankenhaus, Med. Klinik I; Klinik für Hämatologie,Onkologie u. Gastroenterologie, Mönchengladbach
Azienda Ospedaliera Universitaria di Modena, Modena
Universitätsklinikum Essen; Innere Klinik und Poliklinik für Tumorforschung, Essen
Prosper-Hospital, Medizinische Klinik I, Recklinghausen
Hospital de Basurto; Servicio de Hematologia, Bilbao
Hotel Dieu; Medecine D, Angers
Klinik der Uni zu Köln; Klinik für Innere Medizin, Cologne
Siouxland Hematology/Oncology, Sioux City
St.-Antonius-Hospital gGmbH; Klinik für Hämatologie und Onkologie, Eschweiler
Krankenhaus der Barmherzigen Brüder Trier; Innere Medizin I, Hämatologie / Internistische Onkologie, Trier
Uni. der Johannes Gutenberg-Universitaet Mainz; III. Medizinische Klinik und Poliklinik, Mainz
Institut für Versorgungsforschung in der Onkologie GbR Koblenz, Koblenz
Kath. Krankenhaus Hagen gem. GmbH, St.-Josefs-Hospital; Klinik für Hämatologie und Onkologie, Hagen
MT Cancer Inst Fndtn; MT Can Spec, Missoula
A.O. Univ.Ospedali Riuniti Umerto I -G.M.Lancisi G.Salesi; U.O. Clinica Di Ematologia, Torrette DI Ancona
Klinik Johann Wolfgang von Goethe Uni; Medizinische Klinik II, Frankfurt
Illinois Cancer Care, P.C. - Galesburg, Galesburg
Chu Estaing; Hematologie Clinique Adultes, Clermont-Ferrand
Universitaetsklinikum des Saarlandes; medizinische Klinik und Poliklinik; Innere Medizin I, Homburg/Saar
Helios Dr. Horst Schmidt Kliniken; Klinik Innere MED III: Hämatologie, Onkologie, Palliativmedizin, Wiesbaden
Mercy Medical Research Institute, Springfield
Hopital Saint Jean; Hematologie, Perpignan
Praxis für Hämatologie & Onkologie, Saarbrücken
University of Kansas; Medical Center & Medical pavilion, Westwood
Gemeinschaftspraxis Dr. med. Holger Klaproth, Neunkirchen/Saar
Gemeinschaftspraxis für Hämatologie und Onkologie, Lebach
Klinikum der Stadt Ludwigshafen; Medizinische Klinik A, Ludwigshafen
Mannheimer Onkologie Praxis Dres. Jürgen Brust Dieter Schuster, Mannheim
Klinikum Mannheim III. Medizinische Klinik, Mannheim
Dres.Andreas Karcher und Stefan Fuxius, Heidelberg
Uniklinik Heidelberg, Medizinische Klinik & Poliklinik V, Heidelberg
Clinique Victor Hugo, LeMans
Universität Tübingen; Med. Klinik; Innere Medizin I, Tübingen
Highlands Oncology Group, Springdale
Kliniken Ostalb, Stauferklinikum Schwäbisch-Gmünd; Zentrum für Innere Medizin, Mutlangen
Universitätsklinikum Freiburg; Klinik für Innere Medizin I; Hämatologie/Onkologie, Freiburg im Breisgau
Klinikum der Universität München, Campus Großhadern; Medizinische Klinik und Poliklinik III, München
Klinikum rechts der Isar der TU München; III. Medizinischen Klinik (Hämatologie/Onkologie), München
Kootenai Cancer Center, Post Falls
Tagesklinik Landshut; Hämatologie/Onkologie, Landshut
San Juan Oncology Associates, Farmington
Universtitätsklinikum Ulm; Klinik für Innere Medizin III, Ulm
Ospedale V. Cervello; U.O. Ematologia E Trapianti, Palermo
The Regents of the University of California; Office of Research, Irvine
Krankenhaus Barmherziger Brüder; Klinik für Internistische Onkologie / Hämatologie, Regensburg
Hämatologisch-Onkologische Schwerpunktpraxis Dres. Schlag & Schöttker, Würzburg
Providence St. Vincent Medical Center, Portland
Northwest Medical Specialties, Tacoma
HELIOS Klinikum Erfurt I.Medizinische Klinik, Erfurt
Cancer Hospital Chinese Academy of Medical Sciences., Beijing
Peking University First Hospital, Beijing
Beijing Cancer Hospital, Beijing
General Hospital of Chinese PLA; Department of Hematology, Beijing
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF, Moscow
the First Hospital of Jilin University, Changchun
Harbin Medical University Cancer Hospital, Harbin
Republican Clinical Hospital n.a. Baranov; Haematology, Petrozavodsk
Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital), Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Jiangsu Province Hospital, Nanjing
Jiangsu Cancer Hospital, Nanjing
Fujian Medical University Union Hospital, Fuzhou
Union Hospital of Tongji Medical College, Dept. of Cancer Center; Cancer Center, Wuhan
Sun Yet-sen University Cancer Center, Guangzhou
Regional Clinical Hospital N.A. Semashko; Hematology, Nizhny Novgorod
Rambam Medical Center; Heamatology & Bone Marrow Transplantation, Haifa
Beilinson Medical Center; Haematology, Petah Tikva
Chaim Sheba Medical Center; Hematology BMT & CBB, Ramat Gan
Cancer Center of Kansas, Wichita
Tom Baker Cancer Centre-Calgary, Calgary
Cross Cancer Institute, Edmonton
Dr. Georges L. Dumont University Hospital Centre, Moncton
Ottawa General Hospital, Ottawa
North York General Hospital, Toronto
Humber River Hospital, Toronto
Toronto East General Hospital; Haematology/Oncology, Toronto
Hopital Charles Lemoyne; Centre Integre de Lutte Contre Le Cancer de La Monteregie, Greenfield Park
Fakultni nemocnice Brno; Interni hematologicka a onkologicka klinika, Brno
Fn Hr. Kralove; IV. Interni Hematologicka Klinika, Hradec Králové
Vseobecna Fakultni Nemocnice v Praze, I. Interni Klinika - Klinika Hematoonkologie VFN a 1. LF UK, Prague
Helsinki University Central Hospital; Dept of Oncology, Helsinki
Klinikum Chemnitz gGmbH Krankenhaus Küchwald Klinik f.Innere Medizin III, Chemnitz
Städtisches Klinikum Dessau, Dessau
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie, Dresden
Gemeinschaftspraxis Dr. med. J. Mohm und Dr. med. G. Prange-Krex; Fachaerzte fuer Innere Medizin, Dresden
Universitätsklinikum Jena; Klinik für Innere Medizin II, Jena
Klinikum St.Georg gGmbH Klinik für Internistische Onkologie und Hämotologie, Leipzig
Az. Osp. S. Camillo Forlanini; Uo Ematologia E Trapianti Di Midollo Osseo, Rome
Aichi Cancer Center Hospital; Hematology and Cell Therapy, Aichi
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital; Hematology & Oncology, Aichi
Nagoya City University Hospital; Hematology and Oncology, Aichi
Aomori Prefectural Central Hospital; Hematology, Aomori
Chiba Cancer Center;Hematology and Oncology, Chiba
National Cancer Center Hospital East;Hematology, Chiba
Shikoku Cancer Center; Hematology and Oncology, Ehime
National Hospital Organization Kyushu Cancer Center; Hematology, Fukuoka
Gunma University Hospital;Hematology, Gunma
Hiroshima University Hospital; Hematology, Hiroshima
Kobe City Medical Center General Hospital; Hematology, Hyōgo
Hyogo Cancer Center; Department of hematology, Hyōgo
Tokai University Hospital; Hematology, Kanagawa
Kumamoto University Hospital; Hematology Rheumatology and Clinical Immunology, Kumamoto
University Hospital, Kyoto Prefectural University of Medicine; Hematology, Kyoto
Tohoku University Hospital; Hematology and Immunology, Miyagi
Shinshu University Hospital; Hematology, Nagano
Niigata Cancer Center Hospital; Internal Medicine, Niigata
Matsushita Memorial Hospital; hematology, Osaka
Jichi Medical University Hospital; Hematology, Tochigi
National Cancer Center Hospital; Hematology, Tokyo
Toranomon Hospital; Hematology, Tokyo
The Cancer Institute Hospital of JFCR; Hematology Oncology, Tokyo
The Jikei University Daisan Hospital; Department of Clinical Oncology and Hematology, Tokyo
Hospital Universitari Germans Trias i Pujol; Servicio de Hematologia, Badalona
Corporacio Sanitaria Parc Tauli; Servicio de Hematologia, Sabadell
Sahlgrenska Universitetssjukhuset; Sektionen för hematologi och koagulation, Gothenburg
Aberdeen Royal Infirmary; Haematology - Ward 16, Aberdeen
Queen Elizabeth Hospital; Centre for Clinical Haematology, Birmingham
Royal Bournemouth General Hospital; Haematology, Bournemouth
Bristol Haematology and Oncology Centre, Bristol
Addenbrookes Hospital; Haematology, Cambridge
Kent & Canterbury Hospital; Clinical Haematology, Canterbury
Velindre NHS Trust; Haematology Department, Cardiff
Castle Hill Hospital; The Queens Centre for Oncology and Haematology, Cottingham
Western General Hospital; Department of Haematology, Edinburgh
Beatson West of Scotland Cancer Centre, Glasgow
James Paget Hospital; Haematology Department, Great Yarmouth
Princess Alexandra Hospital; Department of Haematology, Harlow
St James Uni Hospital; Icrf Cancer Medicine Research Unit, Leeds
Leicester Royal Infirmary; Dept of Haematology, Leicester
St Bartholomew's Hospital, London
King'S College Hospital; Haematology, London
St. George'S Hospital; Haematology, London
Hammersmith Hospital; Haematology, London
University College Hospital; Macmillan Cancer Centre, London
Christie Hospital; Breast Cancer Research Office, Manchester
Norfolk & Norwich Hospital; Dept of Haematology, Norwich
Nottingham City Hospital; Dept of Haematology, Nottingham
Churchill Hospital; Oxford Cancer and Haematology Centre, Oxford
Queen Alexandra Hospital; Haematology and Oncology Centre, Portsmouth
Southampton General Hospital; Medical Oncology, Southampton
Royal Marsden Hospital; Dept of Medical Oncology, Sutton
Singleton Hospital; Pharmacy, Swansea
Great Western;Department of Haematology, Swindon
Royal Cornwall Hospital; Haematology Clinic, Truro
German Low Grade Lymphoma Study Group
OTHER
Institute of Cancer Research, United Kingdom
OTHER
Hoffmann-La Roche
INDUSTRY