TPI 287 in Breast Cancer Metastatic to the Brain

"Starting dose Phase I: 160 mg/m2 by vein over 60 minutes on Days 1, 8, and 15 of every 28 day cycle.~Starting Dose Phase II: Maximum tolerated dose from Phase I."

6 mg by mouth at 12 hours and 6 hours prior to treatment. As alternative and based on the treating physician discretion, dexamethasone 10 mg by vein may be given 30-60 minutes prior to treatment with TPI 287.

12.5-25 mg intravenous (IV) push 30-60 minutes prior

As H2 blocker 1mg/kg IV 30-60 minutes prior