A Pharmacokinetic Study of AMG 386 in Cancer Subjects With Normal and Impaired Renal Function

PHASE1CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

September 19, 2011

Primary Completion Date

February 26, 2013

Conditions
Advanced Solid TumorsKidney DiseaseRenal Impairment
Interventions
DRUG

AMG 386 + Paclitaxel

15 mg/kg IV (in the vein) of AMG 386 weekly + 80 mg/m\^2 IV (in the vein) 3 weeks on/1 week off, optional beginning week 6 until progression, unacceptable toxicity, or withdrawal of consent.

DRUG

AMG 386

15 mg/kg IV (in the vein) weekly beginning week 1 day 1 until progression, unacceptable toxicity, or withdrawal of consent.

Trial Locations (4)

30332

Research Site, Atlanta

44106

Research Site, Cleveland

60637

Research Site, Chicago

03756

Research Site, Lebanon

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT01331941 - A Pharmacokinetic Study of AMG 386 in Cancer Subjects With Normal and Impaired Renal Function | Biotech Hunter | Biotech Hunter