50
Participants
Start Date
August 22, 2011
Primary Completion Date
July 21, 2019
Study Completion Date
July 21, 2019
Ofatumumab
1000 mg by vein on Day 1 and 2000 mg by vein on Day 8
Ifosfamide
3.33 gm/m2 by vein on Days 2, 3, and 4 continuously.
Etoposide
150 mg/m2 by vein over 2 hours every 12 hours Days 2, 3, and 4 for 6 doses.
Mesna
"2 gm/m2 by vein over 1 hour on Day 2 (given before Ifosfamide starts)~2.66 gm/m2/day by vein continuous infusion given over 24 hours daily for 3 days starting on Day 2 (together with Ifosfamide)~After Ifosfamide/Mesna, 2 gm/m2 by vein given over 12 hours for one dose."
G-CSF
6 mcg/kg subcutaneously twice a day on day 6 (rounded off to the nearest vial) until completion of apheresis.
Stem Cell Collection
Blood stem cells will be collected when blood counts have returned to normal (about 10-16 days after chemotherapy). Stem cell collection takes about 4 hours each time.
University of Texas MD Anderson Cancer Center, Houston
Collaborators (1)
Novartis
INDUSTRY
M.D. Anderson Cancer Center
OTHER