Open Label Extension Study of Conatumumab and Ganitumab (AMG 479)

The mFOLFOX6 regimen is a combination therapy of oxaliplatin 85 mg/m² administered as a 2-hour intravenous (IV) infusion on day 1 and leucovorin 400 mg/m² racemate or 200 mg/m² levo-leucovorin administered as a 2-hour infusion on day 1, followed by a loading dose of 5-fluorouracil (5-FU) 400 mg/m² IV bolus administered on day 1, then 5-FU 2400 mg/m² via ambulatory pump administered for a period of 46 to 48 hours every 14 days.

Administered by intravenous infusion Q2W or Q3W.

Administered by intravenous infusion Q3W or Q4W.

Administered at a dose of 5 mg/kg by intravenous infusion on day 1 of each 14 day cycle.