Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)

PHASE2CompletedINTERVENTIONAL
Enrollment

81

Participants

Timeline

Start Date

March 31, 2011

Primary Completion Date

April 30, 2014

Study Completion Date

February 29, 2016

Conditions
GIST
Interventions
DRUG

Pazopanib

Pazopanib is administered orally at 800 mg/day (one dose every morning). A dose modification is possible in case of documented toxicity, according to specific algorithms.

OTHER

Best supportive care

"Best supportive care according to the investigator's judgment (chemotherapy, immunotherapy, hormone therapy are not allowed).~Non-targeted radiation therapy is tolerated, as antalgic strategy. Surgery is tolerated in case of emergency."

Trial Locations (13)

Unknown

Institut Bergonié, Bordeaux

Centre Georges François Leclerc, Dijon

Centre Oscar Lambret, Lille

Hôpital de la Timone, Marseille

Institut Paoli Calmette, Marseille

Centre Alexis Vautrin, Nancy

Institut de Cancérologie de l'Ouest, Nantes

Hôpital St Antoine, Paris

Hôpital Tenon, Paris

CHU de Reims, Reims

Institut Cancerologie Neuwirth, Saint-Priest-en-Jarez

Institut Gustave Roussy, Villejuif

F-69008

Centre Léon Bérard, Lyon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

Centre Leon Berard

OTHER