Ranibizumab and the Risk of Arterial Thromboembolic Events

PHASE4TerminatedINTERVENTIONAL
Enrollment

380

Participants

Timeline

Start Date

June 30, 2010

Primary Completion Date

October 31, 2012

Study Completion Date

April 30, 2015

Conditions
Age-related Macular DegenerationCoronary Artery DiseaseCerebrovascular Disorders
Interventions
DRUG

0.5 mg of ranibizumab

Intravitreous ranibizumab (0.5 mg, injections at four week intervals for six months followed by further treatment at three month intervals with total duration of treatment until 24 months).

PROCEDURE

0.5 mg of ranibizumab + photodynamic therapy

Photodynamic treatment with ranibizumab for predominantly classic type neovascular age related macular degeneration.

OTHER

Sham injection

Sham treatment for occult or minimally classic type neovascular age related macular degeneration.

Trial Locations (2)

620144

Ural Institute of Cardiology, Yekaterinburg

3071PR

De Haar Research Foundation, Rotterdam

Sponsors
All Listed Sponsors
collaborator

Ural Institute of Cardiology

OTHER

collaborator

De Haar Research Foundation

OTHER

lead

Ural State Medical University

OTHER