A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

342

Participants

Timeline

Start Date

February 28, 2011

Primary Completion Date

February 28, 2013

Study Completion Date

February 28, 2013

Conditions
Major Depressive Disorder
Interventions
DRUG

EB-1010 25mg BID

capsule once daily

DRUG

SSRI Active

Active Comparator

DRUG

EB-1010 50mg BID

Experimental Active

DRUG

Placebo

Placebo comparator

Trial Locations (43)

10029

Mount Sinai School of Medicine, New York

10305

Behavioral Medical Research of Staten Island, Staten Island

18103

Lehigh Valley Hospital, Allentown

18503

Scranton Counseling Center, Scranton

19008

Southeastern PA Medical Institute, Broomall

19063

Suburban Research Associates, Media

19104

University of Pennsylvania, Philadelphia

19139

CRI Worldwide, Philadelphia

21061

Clinical Insights, Glen Burnie

23219

VCU, Richmond

29651

Radiant Research, Greer

30308

Atlanta Center for Medical Research, Atlanta

32216

Clinical Neuroscience Solution, Inc., Jacksonville

32751

Florida Clinical Research Center, Maitland

32771

Medical Research Group of Central Florida, Sanford

32806

Clinical Neuroscience Solutions, Inc, Orlando

33134

Sanitas Research, Coral Gables

37212

Vanderbilt University Medical Center, Nashville

38119

Clinical NeuroScience Solutions, Inc., Memphis

43623

Neurology and Neuroscience Center of Ohio, Toledo

44130

North Star Medical Research, Middleburg Heights

45227

Community Research, Cincinnati

45417

Midwest Clinical Research Center, Dayton

53562

Dean Foundation for Health, Research & Education, Middleton

60076

Psychiatric Medicine Associates, Stokie

60563

AMR Baber Research, Naperville

63301

St Charles Psychiatric Associates, Saint Charles

70601

Lake Charles Clinical Trials, Lake Charles

73112

SP Research, PLLC, Oklahoma City

75231

FutureSearch Trials of Dallas, Dallas

80239

Radiant Research, Inc., Denver

84058

Aspen Clinical Research, Orem

84123

Radiant Research, Inc., Murray

90210

Southwest Research, Inc., Beverly Hills

91007

Pacific Clinical Research Medical Group, Arcadia

91786

Pacific Clinical Research Medical Group, Upland

91950

Synergy Clinical Research Center, National City

92705

Clinical Innovations, Inc., Santa Ana

06360

Comprehensive Psychiatric Care, Norwich

02139

Cambridge Health Alliance, Cambridge

02721

AccelRx Research, Fall River

08540

Global Medical Institutes, Princeton

08046

CRI Worldwide, LLC, Willingboro

Sponsors
All Listed Sponsors
lead

Euthymics BioScience, Inc.

INDUSTRY

NCT01318434 - A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) | Biotech Hunter | Biotech Hunter