Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated Locally Advanced SCCHN

Single dose Panitumumab 9mg/kg IV (in the vein) prior to definitive therapy (surgery or radiation therapy). Two additional doses of panitumumab 9mg/kg IV may be given at weeks 1 \& 4 of RT alone or weeks 1 \& 4 of cisplatin/RT if they tolerated first dose of panitumumab.

Second biopsy was taken from surgical resection tissue (when possible obtained pre and post panitumumab biopsies from the same site).

Radiation therapy was initiated within 8 weeks after surgery, or as soon as possible.